Pfizer A5961166 : Essai de phase 2 évaluant l’efficacité d'une chimiothérapie associant l’irinotécan et le témozolomide, chez des enfants ayant un médulloblastome ou un gliome de haut grade. [Essai clos aux inclusions pour les patients ayant un gliome]. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] L’objectif de cet essai est d’évaluer l’efficacité d'un traitement de chimiothérapie associant l’irinotécan et le témozolomide, chez des enfants ayant un médulloblastome réfractaire ou en rechute ou u...

• Pays France
• Organes Cerveau
• Spécialités Chimiothérapie, Pédiatrie

EFFICACY AND SAFETY OF ERAXIS™/ECALTA® (ANIDULAFUNGIN) COMPARED TO CANCIDAS® (CASPOFUNGIN) IN NEUTROPENIC PATIENTSWITH INVASIVE CANDIDA INFECTION •To assess the efficacy of anidulafungin and caspofungin with respect to the overall global response (clinical and microbiological success) at the EOIVT in neutropenic subjects with a confirmed diagno...

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• Organes Aucun
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Étude A6181196 : étude de phase 1-2 évaluant la sécurité d’emploi de sunitinib chez des jeunes patients ayant une tumeur stromale gastro-intestinale (GIST) avancée. L’objectif de cette étude est d’évaluer la sécurité d’emploi de sunitinib chez des jeunes patients ayant une tumeur stromale gastro-intestinale (GIST) avancée. Les patients sont répartis en deux grou...

• Pays France
• Organes Tumeurs stromales digestives (GIST)
• Spécialités Thérapies Ciblées

Effect of valdecoxib pretreatment on pain and secondary hyperalgesia associated with the heat/capsaicin model in healthy volunteers Not provided at time of registration

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• Organes Aucun
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A phase II double-blind, randomised controlled trial of VEGF inhibitor axitinib monotherapy with early dynamic contrast-enhanced ultrasound monitoring in chemo-refractory third-line metastatic colorectal cancer http://www.cancerresearchuk.org/cancer-help/trials/a-trial-looking-axitinib-advanced-bowel-cancer-axmus-c

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• Organes Aucun
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A RANDOMIZED, DOUBLE-BLIND, PARALLEL-GROUP MULTI-CENTER COMPARATIVE FLEXIBLE-DOSE STUDY OF PREGABALIN VERSUS LEVETIRACETAM AS ADJUNCTIVE THERAPY TO REDUCE SEIZURE FREQUENCY IN SUBJECTS WITH PARTIAL SEIZURES (A0081157) To compare the efficacy of pregabalin and levetiracetam, at doses up to the maximal ones used in pivotal registration trials, as adjunctive therapy in subjects with refractory partial seizures, under ...

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• Organes Aucun
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A trial to evaluate the effectiveness and safety of intravenous Sildenafil in the treatment of neonates with persistent pulmonary hypertension of the newborn or hypoxic respiratory failure and risk for PPHN The primary objectives of this study are to evaluate the efficacy and safety of IV sildenafil when added to iNO for the treatment of neonates with PPHN or hypoxic respiratory failure and at risk for P...

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• Organes Aucun
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PHASE 4, PROSPECTIVE, MULTI-NATIONAL, RANDOMIZED, DOUBLE-BLIND, PLACEBO- CONTROLLED STUDY TO EVALUATE SMOKING CESSATION WITH VARENICLINE TARTRATE COMPARED WITH PLACEBO IN THE SETTING OF PATIENT SELF-SELECTED (FLEXIBLE) QUIT DATE The primary efficacy objective of this protocol is to compare 12 weeks of treatment with varenicline 1 mg BID to placebo for smoking cessation in the setting of a patient selfselected quit date (befor...

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• Organes Aucun
• Spécialités Aucune

A 12-week randomised, evaluator-masked, parallel-group, multinational, multi-centre study comparing the efficacy and safety of the fixed combination of latanoprost and timolol (XalacomTM) with the fixed combination of dorzolamide and timolol (Cosopt®) in subjects with open-angle glaucoma or ocular hypertension To demonstrate the mean diurnal IOP reducing effect of Xalacom™ administered once daily in the evening is non-inferior to that of Cosopt administered twice daily from Baseline to Week 12.

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A randomised, double blind, placebo-controlled, multicentre study in asymptomatic HIV infected patients to investigate pharmacodynamics, pharmacokinetics, safety and toleration of UK-453,061 Investigate the effects of 7-day monotherapy of UK-453,061 on viral load response in asymptomatic HIV infected patients and to assess the dose-response relationship. Assess the pharmacokinetics, safet...

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• Organes Aucun
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