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Double blind, randomized, placebo-controlled, two-way crossover, pilot study to assess the effect of high dose N-acetylcysteine on small airways and on inflammation and oxidative stress in COPD patien...

Mise à jour : Il y a 5 ans
Référence : EUCTR2008-006837-28

Double blind, randomized, placebo-controlled, two-way crossover, pilot study to assess the effect of high dose N-acetylcysteine on small airways and on inflammation and oxidative stress in COPD patients

Femme et Homme

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Extrait

The primary objectives of this study are to assess the effect of high dose NAC (1800 mg): •On small airways by measuring the total and peripheral airway resistance calculated with CFD •On oxidative stress by measuring exhaled NO and oxidative stress markers (CRP, erythrocyte sedimentation rate, glutathione, GPX, SOD, IL-8, IL-6 and 8-isoprostane) in blood and EBC measured at baseline, after 12 weeks of placebo and 12 weeks of NAC.

Critère d'inclusion

  • Chronic Obstructive Pulmonary Disease

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