Open, randomized, two-way crossover, pilot study to assess the effect of Salbutamol in comparison with Ipratropium bromide on central and peripheral airway dimensions in COPD patients The primary objective of this study is to assess the effect of a single dose of salbutamol in comparison with ipratropium bromide on central and peripheral small airways with high-resolution/multislic...

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Double blind, randomized, placebo-controlled, two-way crossover, pilot study to assess the effect of high dose N acetylcysteine on small airways and on inflammation and oxidative stress in COPD patients The primary objectives of this study are to assess the effect of high dose NAC (1800 mg): •On small airways by measuring the total and peripheral airway resistance calculated with CFD •On oxidative st...

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A randomized, double-blind, placebo-controlled, two way cross-over study to assess the particle deposition and acute effects of formoterol and budesonide combination therapy (Symbicort® forte Turbohaler®) on the upper airway dimensions in COPD patients Primary objective: To evaluate the effect of the combination therapy on the upper airway dimensions and to assess the particle deposition with Computational Fluid Dynamics (CFD). The parameters that w...

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Open-label, prospective study to assess the effects of formoterol and beclometasone dipropionate combination therapy on central and peripheral airway dimensions in asthmatic patients to evaluate the effect of the combination on central and peripheral airway dimensions with Computational Fluid Dynamics (CFD).

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Double blind, randomized, placebo-controlled, two-way crossover, pilot study to assess the effect of high dose N-acetylcysteine on small airways and on inflammation and oxidative stress in COPD patients The primary objectives of this study are to assess the effect of high dose NAC (1800 mg): •On small airways by measuring the total and peripheral airway resistance calculated with CFD •On oxidative st...

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