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Kusajili – Centralise les essais cliniques mondiaux
Résultat
de votre recherche par promoteur : Philogen S.p.A
Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
A Phase II study of the tumour-targeting human F16IL2 monoclonal antibody-cytokine fusion protein in combination with paclitaxel versus paclitaxel alone in patients with Merkel cell carcinoma. Phase II Studie des tumorspezifischen Antikörpers F16IL2 in Kombination mit Paclitaxel bei Patienten mit metastatischen Merkelzellkarzinom
To compare the efficacy of F16IL2 in combination with paclitaxel vs. paclitaxel monotherapy, in terms of overall survival rate at 12 months after beginning of study treatments, in patients with metast...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
A phase II study of intratumoral application of L19IL2/L19TNF in melanoma patients in clinical stage III or stage IV M1a with presence of injectable cutaneous and/or subcutaneous lesions. Studio di fase II di applicazione intratumorale di L19IL2/L19TNF nei pazienti con melanoma in stadio clinico III o IV M1a con presenza di lesioni iniettabili cutanee e/o sottocutanee
Efficacy of L19IL2/L19TNF-treated lesions measured as : Rate of patients with complete response (CR) of L19IL2/L19TNF-treated lesions at week 12 (day 85). Efficacia del L19IL2/L19TNF sulle lesi...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
A phase II study of L19IL2 injected directly into the tumor in patients with stage III/IV melanoma
Rate of patients with complete response (CR) of L19IL2 treated metastases at week 12
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
Study of Phase I/II of the combination of L19IL2 with Rituximab in Diffuse Large B-cell Lymphoma
Phase I: 1) To assess the MTD and monitor the safety of L19IL2 in combination with Rituximab in patients with relapsed or refractory DLBCL and to describe DLT. 2) To define the RD of L19IL2 to be used...
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unknown
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
A PHASE I/II DOSE FINDING AND EFFICACY STUDY OF THE TUMOUR TARGETING HUMAN 131I-L19SIP MONOCLONAL ANTIBODY IN PATIENTS WITH CANCER
Phase I: - Determination of maximum tolerated dose and recommended dose Phase II: - Investigation of the antitumor activity at the recommended dose in cancer patients (objective response rate)
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
Study of the efficacy of intratumoral injections of L19IL2/L19TNF followed by surgery to prevent or retard appearance of new metastases
Efficacy of L19IL2/L19TNF measured as recurrence-free survival (RFS) rate in the L19IL2/L19TNF plus surgery treatment group (Arm 1) versus surgery alone (Arm 2), assessed at 1 year after randomizatio...
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unknown
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
A multicenter, placebo-controlled phase II study to evaluate safety and clinical efficacy of two different doses of F8IL10 administered subcutaneously to patients with active rheumatoid arthritis receiving Methotrexate
Mean change from baseline in DAS28-CRP between F8IL10 and placebo arms at week 9.
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unknown
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
A Phase I/II Dose Escalation study of the tumor-targeting L19-IL2 antibody-cytokine in combination with Dacarbazine for patients with metastatic melanoma
Phase I: Maximum tolerated dose (MTD) and the recommended dose (RD) of L19IL2 for phase II when administered in combination with a fixed dose of DTIC. Phase II: Antitumor activity in terms of be...
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
Dose definition and activity evaluation study of the tumor-targeting human L19IL2 monoclonal antibody-cytokine fusion protein in combination with Dacarbazine in patients with metastatic melanoma
Phase IIa part: - To establish the recommended dose (RD) of L19IL2 when administered in combination with a fixed dose of DTIC in patients with metastatic melanoma, the preliminary tolerability profil...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
Philogen S.p.A
MAJ Il y a 4 ans
A prospective non-randomized study of 131I-L19SIP Radioimmunotherapy (RIT) in combination with Whole Brain Radiation Therapy (WBRT) in patients with multiple brain metastases from solid tumors
To evaluate the safety of the administration of radioimmunotherapy with 131I-L19SIP combined with whole brain radiation treatment (the standard treatment)and to determine the selective uptake of the s...
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unknown
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