Therapeutic Interventions for Stones of the Ureter Background and study aims Ureteric stones (kidney stone) are very common and painful; 2-3% of the general population (1.8 million in the UK) have suffered from this condition. Ureteric stones can pass...

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A study to observe the effects of one month’s supplementation with forceval junior on asthma control in children aged 7-12 years with asthma What is the compliance with Forceval Junior Capsules when prescribed as part of a clinical trial in children with asthma?

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Does nitrite reduce ischaemia-reperfusion injury in patients with acute ST segment elevation myocaridal infarction? In patients who have had a heart attack and are undergoing percutanuous coronary intervention (angioplasty), does a 5 minute intravenous injection of sodium nitrite immediately prior to opening of an ...

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Does an interactive summary of findings table improve users’ understanding of and satisfaction with information about the benefits and harms of treatments? Background and study aims We all need to make decisions about our health and treatments, and health and health research are often in the news. Information about treatments is sometimes confusing or ha...

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PRO-MAN study: To determine whether nutrition counselling and self-help resources will affect body weight and quality of life of prostate cancer patients Background and study aims We are carrying out a study among prostate cancer patients to assess the feasibility of monthly individually-tailored telephone calls and the engagement of the patients in we...

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Is cessation of clopidogrel therapy associated with rebound of platelet activity in stable vascular disease patients? Not provided at time of registration

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The use of Ketamine as an anaesthetic during electroconvulsive therapy (ECT) for depression: does it improve treatment outcome? The main research question is whether the use of ketamine as the anaesthetic for ECT treatment for depression improves the treatment outcome with respect to speed of response and reduction in side eff...

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Dose escAlation study of Melatonin in Sepsis: healthy voLunteers Background and study aims Patients who are admitted to an Intensive Care Unit with severe infections (called sepsis) have a very high risk of death. We have shown in laboratory studies that melatonin...

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Preventing Recurrence of Endometriosis by means of long acting Protestogen Therapy Main study principal objective To compare, in women undergoing conservative surgery for pain due to endometriosis, the effectiveness of some or all of the following four post-surgical treatment option...

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Enumeration and Functional Evaluation of Regulatory T-cells in Psoriasis Patients Before and After Treatment with: Calcipotriol/Betamethasone, Acitretin, Narrow-Band UVB and Anti-TNF α Therapy (Etanercept, Adalimumab and Infliximab) 1) The objective is to test whether patient's response to conventional currently used psoriasis treatment, used in normal clinical practice is determined by regulatory T cells (cells which control the...

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