A randomized, placebo-controlled, 2-way crossover, double-blind study to evaluate the efficacy, safety and tolerability of JNJ-42847922 in subjects with insomnia disorder without psychiatric disease The primary purpose of this study is to investigate the effect of JNJ-42847922 (change versus placebo) on sleep efficiency (SE) measured by polysomnography (PSG) after single and multiple dose adminis...

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A Golimumab Phase 3b, Multicenter, Switch Assessment of Subcutaneous and Intravenous Efficacy in Rheumatoid Arthritis Patients Who Have Inadequate Disease Control Despite Treatment with Etanercept (ENBREL®) or Adalimumab (HUMIRA®) The primary objective of this study is to evaluate the efficacy of golimumab + MTX in reducing signs and symptoms of RA (as assessed by the American College of Rheumatology [ACR] 20) at Week 14 in pat...

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CR100848 : Etude de phase 3, multicentrique, contrôlée, randomisée, en ouvert, évaluant un inhibiteur de la tyrosine kinase de Bruton (Btk), ibrutinib, versus temsirolimus, chez des patients ayant un lymphome à cellules du manteau en rechute ou réfractaire après au moins une ligne de traitement. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] L’objectif de cet essai est de comparer l’efficacité et la tolérance de deux traitements, l’ibrutinib et le temsirolimus, chez des patients ayant un lymphome à cellules du manteau, réfractaire ou en r...

• Pays France
• Organes Lymphomes non hodgkinien
• Spécialités Thérapies Ciblées

A Long-term Extension Study of PCI-32765 (Ibrutinib) The objective of this study is to collect long-term safety and efficacy data for subjects treated with PCI-32765 and to provide ongoing access to PCI-32765 for subjects who are currently enrolled in P...

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Early Labour Assessment and Support at Home To determine, among healthy first time mothers who are uncertain as to when to come to hospital in labour, if home visits by obstetrical nurses compared to telephone advice have an impact ...

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A Study to Evaluate the Efficacy and Safety of Rivaroxaban Venous Thromboembolism (VTE) Prophylaxis in Ambulatory Cancer Participants The primary efficacy objective is to demonstrate that rivaroxaban is superior to placebo for reducing the risk of the primary composite outcome as defined by objectively confirmed symptomatic lower ex...

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Étude TITAN : étude de phase 3 randomisée visant à comparer l’efficacité de l’apalutamide associé à un traitement par suppression androgénique à un traitement par suppression androgénique seul chez des patients ayant un cancer de la prostate hormono-sensible métastatique. [essai clos aux inclusions] Le cancer de la prostate prend naissance dans les cellules de la prostate et il est d’évolution lente, mais il peut se propager à d’autres parties du corps, donnant lieu aux métastases. L’adénocarcino...

• Pays France
• Organes Prostate
• Spécialités Chimiothérapie, Hormonothérapie

A randomized, Double-Blind, Active-Controlled, Parallel-Group, Noninferiority, Multicenter Study of Ceftobiprole Medocaril Versus Cefepime With or Without Vancomycin in the Treatment of Subjects With Fever and Neutropenia To demonstrate the noninferiority of ceftobiprole compared with cefepime with or without vancomycin in subjects with fever and neutropenia with regard to clinical cure versus not cured, after completi...

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Comparison of Ionsys® and routine care with morphine IV PCA in the management of early post-operative mobilisation, ability to mobilise and in time to Fitness For Discharge (FFD) The primary objective of this study is to demonstrate the superiority of Ionsys over morphine IV PCA with regard to the patient's ability to mobilise during the management of acute moderate to severe ...

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A Randomized Double-blind study of Ustekinumab in Pediatric Subjects with Crohn's Disease - Evaluate the pharmacokinetics (PK) of ustekinumab in subjects from 2 through <18 years old and determine if it is similar to that observed in adults with moderately to severely active CD. - Assess ...

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