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Kusajili – Centralise les essais cliniques mondiaux
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de votre recherche span> par promoteur : AstraZeneca AB
Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A clinical trial to assess the efficacy and safety of aclidinium bromide 400 mcg/formoterol fumarate 12 mcg combination taken twice daily compared with each individual component (aclidinium bromide 400 mcg twice daily and formoterol fumarate 12 mcg twice daily) and tiotropium 18 mcg once daily when administered to patients with stable chronic obstructive pulmonary disease. Ensayo Ccínico para evaluar la eficacia y seguridad de una combinación de bromuro de aclidinio 400 mcg/formoterol fumarato 12 mcg tomadas dos veces/día comparada con cada componente individual (bromuro de aclidinio 400 mcg dos veces/día y formoterol fumarato 12 mcg dos veces/día) y tiotropio 18 mcg una vez al día cuando se administra a pacientes con enfermedad pulmonar obstructiva crónica estable
Primary Objective for EU: To assess the non-inferior bronchodilation of AB 400 ?g BID as compared to TIO 18 ?g QD in COPD patients. Primary Objectives for USA: To assess the bronchodilatory effect o...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Randomized, Double-Blind, Placebo-Controlled, Cross-Over Study to Evaluate the Effect of Tesaglitazar 1 mg once daily on the Pharmacokinetics of Metformin Following Addition of Tesaglitazar to Metformin Treatment twice daily in Patients with Type 2 Diabetes
To compare the effect of 1 mg tesaglitazar once daily versus placebo once daily given as add?on therapy to metformin on the steady state exposure (AUCss) of metformin in patients with type 2 diabetes ...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Phase II, Double-Blind, Placebo Controlled, Randomised Study To Assess The Efficacy And Safety Of 2 Doses Of ZACTIMA (ZD6474) In Combination With FOLFOX vs FOLFOX Alone For The Treatment Of Colorectal Cancer In Patients Who Have Failed Therapy With An Irinotecan And Fluoropyrimidine Containing Regimen
The primary objective of this study is to assess the efficacy of ZD6474 (100 mg and 300 mg) in combination with the modified FOLFOX 6 regimen (mFOLFOX6) versus mFOLFOX6 alone for the treatment of pati...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A randomised, open, phase IV, parallel group multicentre study to evaluate a change of management in Gastroesophageal Reflux Disease (GERD) patients by treatment with esomeprazole 40 mg or any other Proton Pump Inhibitor (PPI), after initial treatment failure, in ordinary clinical practice during 4 weeks
The primary objective of this study is to assess how PPI treated GERD-patients with insufficient symptom control will benefit from a change in management by providing a more efficient acid secretion i...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Phase 2a, double blind, placebo controlled study to evaluate the efficacy of MEDI-563 in subjects with moderate to severe COPD and sputum eosinophilia
The primary objective of this study is to evaluate the effect of multiple subcutaneous (SC) doses of MEDI-563 on the rate of moderate-to-severe acute axacerbations in Chronic Obstructive Pulmonary Dis...
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unknown
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Phase III, Randomized, Double-Blinded, Multi-Centre Study to Assess the Efficacy of Docetaxel (TAXOTERE™) in Combination with ZD6474 (ZACTIMA™) versus Docetaxel (TAXOTERE™) in combination with Placebo in Patients With Locally Advanced or Metastatic (Stage IIIb – IV) Non-small Cell Lung Cancer (NSCLC) after Failure of 1st Line Anti-Cancer Therapy
The primary objective of this study is to demonstrate an improvement in PFS in the combination of ZACTIMA with docetaxel compared with docetaxel plus placebo in patients with locally advanced or metas...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Safety Extension Study with Benralizumab (MEDI-563) for Asthmatic Adults on Inhaled Corticosteroid Plus LABA Ensayo de extensión de seguridad con benralizumab (MEDI-563) en adultos asmáticos con un corticosteroide inhalado más LABA
To assess the safety and tolerability of 2 dosing regimens of benralizumab for adult patients Evaluar la seguridad y la tolerabilidad de 2 pautas posológicas de benralizumab en pacientes adultos
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unknown
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Randomised, Double-Blind, 52-Week, Parallel-Group, Multicentre, Phase IIb Study to Evaluate the Effects of Rosuvastatin 10 mg, Rosuvastatin 40 mg and Atorvastatin 80 mg on Urinary Protein Excretion in Hypercholesterolaemic Diabetic Patients with Moderate Proteinuria PLANET I: Prospective evaLuation of proteinuriA and reNal function in diabETic patients with progressive renal disease
The primary objective of this study is to evaluate the effects of rosuvastatin and atorvastatin on urinary protein excretion by evaluation of the change in urinary protein/creatinine ratio from baseli...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Phase II Randomised, Double-blind, Placebo-controlled, Multicentre Comparative study of ZD1839 250 mg or 500 mg (Iressatm) given either continuously or concomitantly with cisplatin plus radiotherapy for the treatment of patients with previously untreated unresected late stage III/IV non-metastatic head and neck squamous cell carcinoma
The primary objective of the study is to assess the additive effect of ZD1839 250 mg and ZD1839 500 mg (given either concomitantly or as maintenance) over cisplatin plus radiotherapy (RT) in terms of ...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A study to determine how the drug(ATM-AVI) is moved in your body and whether the drug is safe and tolerable for the treatment of complicated Intra-Abdominal Infections (cIAIs) in hospitalized adults Estudio para determinar cómo se mueve la droga (ATM-AVI) en su cuerpo y si el medicamento es seguro y tolerable para el tratamiento de infecciones intra-abdominales complicadas (cIAIs) en adultos hospitalizados
To determine the PK of ATM-AVI and to assess the safety of ATM-AVI in the patient population Determinar la farmacocinética (PK) de ATM-AVI en la población de estudio. Evaluar la seguridad de ATM...
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unknown
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