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Kusajili – Clinical trials directory
Result
of your search per sponsor: F. Hoffmann-La Roche Ltd
Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A multi-center, double-blind, randomized, placebo controlled, dose-ranging phase 2 study to investigate pharmacodynamics, safety, tolerability and pharmacokinetics of RO5073031 in patients with type 2 diabetes mellitus treated with a stable dose of metformin (BC20688)
To determine the efficacy, with respect to glycemic control, of multiple doses and regimens of RO5073031 which, when added to metformin, are safe and tolerable compared with placebo in patients with t...
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A Study Investigating the Efficacy and Safety of Lampalizumab Intravitreal Injections in Patients with Geographic Atrophy Secondary to Age-Related Macular Degeneration (Study #2)
To evaluate the efficacy and safety of 10 mg lampalizumab intravitreal injections of administered every 4 weeks (Q4W) or every 6 weeks (Q6W) in patients compared with sham control assessed by change i...
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
An Open-Label, Observational Study of the Effects of Anti-TNF Therapy on Peripheral Blood and Synovial Biomarkers in Patients with Active Rheumatoid Arthritis
The primary objective of this study is to compare (i) baseline characteristics and (ii) changes over time in a)Ultrasonographic imaging of a discrete joint set including the joints selected for synov...
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
Randomized Phase II study of pertuzumab, trastuzumab and vinorelbine in patients with HER2-positive breast cancer. Ensayo fase II randomizado de pertuzumab, trastuzumab, vinorelbina en pacientes con cáncer de mama avanzado HER-2 positivo
To compare objective overall response rates (ORR) assessed by a blinded independent review committee (IRC) of pertuzumab given in combination with trastuzumab and vinorelbine together in a single infu...
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A Study of Pegasys in Combination with antiviral HBV oral Lamivudine or Entecavir compared against no treatment in Children Positive but tolerant to Chronic Hepatitis B
To evaluate the efficacy of Pegasys® + lamivudine or entecavir compared with an untreated control in children with CHB, as measured by loss of HBsAg 24 weeks post-end of treatment/end of untreated obs...
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
Roche Farma, S.A. en nombre de F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
Safety Efficacy Study in 12-30y old Down Syndrome subjects Estudio de eficacia y seguridad en pacientes con sindrome de Down de 12 a 30 años de edad
The primary objective of this study is as follows: ? To evaluate the efficacy of 26 weeks of treatment with RO5186582 on a composite endpoint derived from clinically meaningful responses in working me...
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A study to assess the efficacy and safety of tocilizumab versus placebo in patients with Systemic Sclerosis
To evaluate the efficacy of tocilizumab (TCZ) compared with placebo on skin sclerosis, as measured by modified Rodnan Skin Score (mRSS) at Week 48
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A multicentre, double-blind randomised, phase III study to evaluate the efficacy of Tarceva or placebo following 4 cycles of platinum-based chemotherapy in patients with histologically documented advanced or recurrent (stage IIIB and not amenable for combined modality treatment) or metastatic (Stage IV) non-small cell lung cancer (NSCLC) who have not experienced disease progression or unacceptable toxicity during chemotherapy
To determine if the administration of Tarceva after standard platinum based chemotherapy in the treatment of NSCLC results in improved Progression Free Survival (PFS) when compared to placebo. 1. In a...
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A study to evaluate the efficacy and the safety of MetMAb in combination with paclitaxel+cisplatin or paclitaxel+carboplatin in patients with either locally advanced or metastatic squamous cell lung cancer
•To evaluate the duration of progression-free survival of MetMAb + paclitaxel + platinum (cisplatin or carboplatin) relative to placebo + paclitaxel + platinum in all enrolled patients and in the sub...
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
F. Hoffmann-La Roche Ltd
Update Il y a 4 ans
A study to evaluate the efficacy and safety of bevacizumab in combination with trastuzumab/docetaxel in patients with breast cancer that spread to other tissues
To compare Progression Free Survival (PFS) in patients randomized to bevacizumab in combination with trastuzumab/docetaxel versus patients randomized to trastuzumab/docetaxel alone
Country
None
organs
None
Specialty
None
Closed trial
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