A Proof-of-Principle Analgesic Adjuvant Pilot Study in Post-Operative Dental Pain To compare the analgesic efficacy of theobromine + paracetamol versus paracetamol alone.

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A Comparison of Two Analgesic Products for the Treatment of Headache To compare total pain relief over 30 minutes (TOTPAR 0-30 minutes) for a rapidly absorbed paracetamol + caffeine (RAPC) tablet versus placebo and versus ibuprofen tablet.

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A Proof of Principle Study to Investigate the Efficacy of a Medical Device and Topical Analgesic Combination for the Treatment of Pain and Performance Related Function in Osteoarthritis The primary objective of this study is to compare the efficacy of 72 hours (hrs) treatment of topical diclofenac plus a heat patch with 72 hrs treatment of topical diclofenac plus a placebo patch on t...

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A Longitudinal MRI Study of Changes in Regional Body Composition During Orlistat (60mg)-Assisted Dieting To examine the use of MRI to assess change-from-baseline in visceral adipose tissue in overweight volunteers following 3 months of orlistat 60mg and a reduced calorie, low fat diet.

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The Effects of Weight Reduction with Orlistat vs. Placebo on Changes in Body Composition To determine whether a 24 week weight loss program with orlistat will produce a greater reduction from baseline in abdominal visceral adipose tissue (VAT) mass compared to placebo in overweight and cl...

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An exploratory study to investigate early dental erosion Background and study aims Dental erosion is the loss of hard tooth enamel caused by acid attack without the involvement of bacteria. The very early stages of erosion involve the softening and loss of ...

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An evaluation of the 4 mg nicotine mint lozenge for the relief of cognitive impairment associated with nicotine withdrawal The primary objective of this study is to compare the effect of the 4 mg nicotine mint lozenge to placebo on ability to concentrate, as measured by the Rapid Visual Information Processing (RVIP) test.

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Clinical Study to Evaluate the Efficacy of Chlorhexidine Mouthwashes To evaluate and compare Gingival Bleeding (as assessed by the gingival severity component of the Gingival Index [GI]) following twice daily use of a non-alcohol 0.2% Chlorhexidine mouthrinse and brush...

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An exploratory, observational cohort study investigating commercially available treatments which may reduce the scab stage of recurrent herpes labialis To investigate the ability of 3 currently available medical device products to impact on the wound healing process of recurrent herpes labialis (RHL) such that the ‘scab’ is either reduced or modified...

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Simultaneous fMRI/EEG of the 4 mg nicotine lozenge in relief of cognitive impairment associated with nicotine withdrawal To compare the effect of the 4 mg nicotine lozenge to placebo on blood oxygen level-dependent (BOLD) activation associated with attention in abstinent smokers.

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