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Kusajili – Centralise les essais cliniques mondiaux
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de votre recherche span> par promoteur : GlaxoSmithKline R & D
Femme et Homme Max 99 ans
GlaxoSmithKline R & D
MAJ Il y a 5 ans
FONDAparinux in patients with a plaster CAST (FONDACAST): A Multicentre, Randomized, Open-label, Controlled, Two-Parallel-Group, Phase III Study to Evaluate the Efficacy and Safety of Fondaparinux versus Low-molecular-Weight Heparin (Nadroparin), in Patients Requiring Rigid or Semi-rigid Immobilization for at least 21 Days and up to 45 Days because of Isolated Non-surgical Below-Knee Injury
The primary objective of the study is to demonstrate the superiority of fondaparinux 2.5 mg (1.5 mg in patients with a creatinine clearance between 30 and 50 mL/min) once daily versus LMWH (nadropari...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D Limited
MAJ Il y a 5 ans
A proof-of-concept study of SB-751689 in men and post-menopausal women with a fractured distal radius
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D
MAJ Il y a 5 ans
SAFE-AF: Safety of Fondaparinux in electric cardioversion of atrial fibrillation. An International, Multicentre, Randomised, Open, Controlled, Two-parallel Group, Phase II Study to Evaluate the Efficacy and Safety of ARIXTRA™ for Anticoagulation of Patients with Atrial Fibrillation undergoing Electric Cardioversion Following Transesophageal Echocardiography
The primary objective of the study is to demonstrate non-inferiority of Fondaparinux once daily versus UFH/oral anticoagulation with respect to the occurrence of cerebral neurologic events, systemic t...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D
MAJ Il y a 5 ans
A Multicenter, Randomized, Double-Blind, Triple-Dummy, Placebo-Controlled, Parallel Group, Four-Week Study Assessing the Efficacy of Fluticasone Propionate Aqueous Nasal Spray 200mcg OD versus Montelukast 10mg OD in Adolescent and Adult Subjects with Asthma and Seasonal Allergic Rhinitis Who are Receiving salmeterol/Fluticasone Propionate DISKUS® 100/50mcg BID or Placebo BID
The main objective of this study are to show that fluticasone propionate/salmeterol combination product 100/50mcg (FSC) BID (available as Seretide DISKUS) is superior to montelukast 10mg OD (available...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D Limited
MAJ Il y a 5 ans
A 54-week, double-blind, randomized, placebo-controlled, parallel-group study to investigate the effects of rosiglitazone (extended release tablets) as adjunctive therapy to acetylcholinesterase inhibitors on cognition and overall clinical response in APOE ε4-stratified subjects with mild to moderate Alzheimer’s disease (REFLECT-3)
The primary objective of this study is to investigate the add-on effects of daily dosing for 48 weeks with RSG XR versus placebo on cognitive function and overall clinical response in AChEI-treated su...
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D
MAJ Il y a 5 ans
A double-blind, randomized, placebo-controlled multi-centre, phase II parallel dose-ranging study to assess the antifibrotic activity of GI262570 in chronic hepatitis C subjects with hepatic fibrosis who have failed prior antiviral therapy
To describe the safety and efficacy of two doses of GI262570 treatment in chronic hepatitis C subjects with Genotype 1 infection, who have failed prior anti-HCV therapy, in improving immunohistochemic...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D
MAJ Il y a 5 ans
A Multicentre, Two-Part, Randomised, Double-Blind, Placebo-Controlled, Parallel-Group Study to Evaluate the Efficacy,Tolerability and Pharmacokinetics of the iNOS Inhibitor GW274150 Administered up to 120mg Daily for 12 Weeks in the Prophylactic Treatment of Migraine
The primary objective of this study is to estimate the dose-response and dose-safety relationships for GW274150 in the prophylaxis of migraine.
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D Limited
MAJ Il y a 5 ans
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase 3 Study to Evaluate the Efficacy and Safety of Alvimopan 0.5mg Once Daily and 0.5mg Twice Daily for 12 Weeks for the Treatment of Opioid-Induced Bowel Dysfunction in Adults taking Opioid Therapy for Persistent Non-Cancer Pain
To compare alvimopan with placebo for efficacy in the treatment of OBD
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D Limited
MAJ Il y a 5 ans
A double-blind, randomised, placebo controlled, three-period crossover study to investigate the pharmacodynamic effect of two CRF-1 antagonists GSK561679 and GW876008 on meal induced cortisol responses in patients with IBS
To determine the pharmacodynamic effect of single doses of GSK561679 and GW876008 on meal induced cortisol responses in patients with IBS.
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Femme et Homme Max 99 ans
GlaxoSmithKline R & D Limited
MAJ Il y a 5 ans
A Randomized, Double-Blind, Placebo-Controlled, Multicenter Phase IIb Study to Evaluate the Efficacy and Safety of Multiple Alvimopan Dosage Regimens for the Treatment of Opioid-Induced Bowel Dysfunction in Cancer Pain Subjects
To identify at least one alvimopan treatment regimen that improves spontaneous complete bowel movement (SCBM) frequency compared to placebo while maintaining an acceptable tolerability profile.
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