Interactive Psychopharmacologic Effects of Alcohol and Nicotine in Humans The purpose of this study is to characterize the interactive effects of acute intravenous (IV) alcohol and nicotine administration in male and female smokers and nonsmokers who use alcohol...

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D-Serine Treatment of Negative Symptoms and Cognitive Deficits in Schizophrenia This study is based on the hypothesis that by increasing N-methyl-D-aspartic acid (NMDA) receptor function in the brain and thereby increasing the capacity of the brain to both form new co...

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Effects of Delta-9-THC and Iomazenil in Healthy Humans The study aims to examine the combined effects of delta-9-tetrahydrocannabinol (∆-9-THC or THC) and iomazenil on thinking, perception, mood, memory, attention, and electrical activity of t...

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Pilot Study of ORG 25935 Modulation of Ketamine-induced Behavioral and Cognitive Effects in Healthy Male Subjects Org 25935 is a new putative antipsychotic agent developed by N.V. Organon.The primary objective of this study is to investigate the effect of Org 25935 on ketamine-induced impairments in i...

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Nicotinic Modulation of Schizophrenia-like Information Processing Deficits in Healthy Subjects This study examines the interactive effects of ketamine and nicotine.

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Cannabinoid Modulation of Pain The purpose of this study is to test the effects of cannabinoids on pain response using a variety of human experimental pain models.

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