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Kusajili – Centralise les essais cliniques mondiaux
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de votre recherche span> par promoteur : AstraZeneca AB
Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A single-centre, single-blind, randomised, placebo-controlled phase IIa study to investigate the effect of AZD1305 given as an iv infusion on left ventricular performance in patients with left ventricular dysfunction
To explore if AZD1305 compromises left ventricular function in patients with left ventricular dysfunction.
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A 4-week randomized, double-blind, placebo controlled, parallel group, phase II study to assess the efficacy and safety of gefitinib tablets, 250 mg once daily (OD), in adult patients with moderate chronic obstructive pulmonary disease (COPD)
To evaluate the efficacy of gefitinib tablets, 250 mg once daily (OD) on symptoms, mainly cough and sputum production, in patients with Chronic Obstructive Pulmonary Disease (COPD) compared to placebo...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A controlled, randomised, double-blind, double-dummy, parallel-group, phase III, multicenter study to evaluate efficacy and safety of the oral direct thrombin inhibitor AZD0837 compared to warfarin for the prevention of stroke and systemic embolic events (SEE) in patients with atrial fibrillation (ASSURE-AF)
The primary objective of this study is to demonstrate that AZD0837 is non-inferior to warfarin, aiming for an INR 2.0 to 3.0, target 2.5, in the prevention of the composite outcome variable of stroke ...
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unknown
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Multi-Centre, Double-Blind, Randomised, Parallel-Group, Placebo-Controlled Phase III Study of the Efficacy and Safety of Quetiapine Fumarate Sustained Release (Seroquel SRTM) as Mono-Therapy in the Treatment of Elderly Patients with Major Depressive Disorder (SAPPHIRE STUDY)
The primary objective of this study is to evaluate the efficacy of quetiapine SR 50-300 mg/day versus placebo in elderly patients with MDD.
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A 12-week, randomised, double-blind, placebo-controlled, parallel group, multinational, phase IIb dose range finding study to evaluate the efficacy and safety of AZD9668 administered orally at 3 dose levels to patients with Chronic Obstructive Pulmonary Disease (COPD) on treatment with tiotropium
To evaluate the dose-response relationship and efficacy of AZD9668 at 3 dose levels compared with placebo in symptomatic COPD patients by assessing effects on lung function and symptoms of COPD.
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A double-blind, randomised, placebo-controlled, parallel-group, multicentre, phase II study to assess the efficacy of AZD7009 (AR-H065522XX) given intravenously (infusion for 15 or 30 minutes) to patients for conversion of atrial fibrillation
To study the efficacy of iv AZD7009 in all treatment groups versus placebo, in conversion of AF. The primary outcome variable for the evaluation of this objective is: -the proportion of patients tha...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A Randomised, Double-Blind, 52-week, Parallel-Group, Multicentre, Phase IIb Study to Evaluate the Effects of Rosuvastatin 10 mg, Rosuvastatin 40 mg and Atorvastatin 80 mg on Urinary Protein Excretion in Hypercholesterolaemic Non-Diabetic Patients with Moderate Proteinuria PLANET II: Prospective evaLuation of proteinuriA and reNal function in non-diabETic patients with progressive renal disease
The primary objective of this study is to evaluate the effects of rosuvastatin and atorvastatin on urinary protein excretion by evaluation of the change in urinary protein/creatinine ratio from baseli...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A 52-week International, Phase 3bTrial with a Blinded 104-week Long - term Extension Period to Evaluate Saxagliptin Co-administered with Dapagliflozin in combination with Metformin Compared to Glimepiride in Combination with Metformin in Patients with Type 2 Diabetes
To compare the mean change from baseline in HbA1c achieved with saxagliptin, in co-administration with dapagliflozin, added to current background therapy with metformin, compared to glimepiride added ...
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unknown
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
Study of Coronary Atheroma by InTravascular Ultrasound: Effect of Rosuvastatin Versus AtorvastatiN (SATURN): A 104-week, randomized, double-blind, parallel group, multi-center Phase IIIb study comparing the effects of treatment with rosuvastatin 40mg or atorvastatin 80mg on atherosclerotic disease burden as measured by intravascular ultrasound in patients with coronary artery disease
The primary objective of this study is to compare the effects of rosuvastatin 40mg with atorvastatin 80mg on the percent atheroma volume (PAV) of a coronary artery as measured by intravascular ultraso...
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Essai clos aux inclusions
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Femme et Homme Max 99 ans
AstraZeneca AB
MAJ Il y a 5 ans
A 4-week double-blind, placebo-controlled, randomised, parallel group phase IIa study to assess the tolerability/safety and efficacy of inhaled AZD4818 in patients with moderate to severe Chronic Obstructive Pulmonary Disease (COPD)
To investigate the tolerability and safety of inhaled AZD4818 delivered via a dry powder inhaler, Turbuhaler®, in COPD patients by assessment of: . incidence and nature of adverse events (AE) . Electr...
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Essai clos aux inclusions
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