Prospective, randomised (using minimisation), double-blind, placebo controlled study to evaluate the safety and efficacy of human normal immunoglobulin as a prophylactic agent against infections in patients with high grade gliomas To determine the number of infective episodes in patients with high grade gliomas during treatment with 10% intravenous immunoglobulin (Kiovig) compared with placebo (normal saline).

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Doppelblinde, randomisierte, prospektive multizentrische klinische Studie zur Definition der optimalen antibiotischen Therapiedauer bei Patienten mit unkomplizierter akuter Cholangitis: Moxifloxacin oral vs. Placebo oral nach Entfieberung zur Fortführung der initial intravenösen Therapie mit Moxifloxacin. Duration of Moxifloxacin therapy for acute cholangitis – a randomized, placebo-controlled, multicenter study. The MONA LISA study Evaluation of the neccessary duration of antibiotic therapy for patients with acute uncomplicated cholangitis.

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A prospective phase I and consecutive phase II, twoarm, randomized multi-center trial of temsirolimus in combination with pioglitazone, etoricoxib and metronomic low-dose trofosfamide versus dacarbazine (DTIC) in patients with advanced melanoma Phase I: To determine the dose of temsirolimus to be used in phase II part of the study Phase II: To determine overall survival

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Die perioperative Anwendung von Etoricoxib verglichen mit Diclofenac bei Patienten nach Implantation einer Hüftgelenkstotalendoprothese, prospektive, doppelt blinde Phase IIIb Studie It will be analyzed whether the use of Etoricoxib as compared to Diclofenac leads to a reduction of the perioperative risk of bleedings. The primary objective of the study is the designation of the ...

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Multicentre pilot-study for the therapy of medulloblastoma of adults (NOA-07) The main objective is the feasibility of the adjuvant chemotherapy which has gained the best results when combined with radiotherapy so far. The present protocol is primarily to determine the number o...

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Die Wirksamkeit einer medikamentösen Behandlung mit SOM230 LAR hinsichtlich Tumorgrößenreduktion bei Patienten mit primär inoperablem Thymom und/oder einem lokalen Thymomrezidiv • Tumor shrinkage Response is defined as the decrease in tumor volume of 20 % at EOS as compared to baseline.

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Treatment of steroid-resistant chronic graft-versus-host-disease with regulatory T cells To examine the safety and MTD Level of in vitro expanded donor regulatory T cells for the Treatment of patients with chronic GVHD

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Prospective randomised multicenter phase-III-study: Preoperative radiochemotherapy and adjuvant chemotherapy with 5-Fluorouracil plus oxaliplatin versus preoperative radiochemotherapy and adjuvant chemotherapy with 5-Fluorouracil for locally advanced rectal cancer To investigate whether the addition of oxaliplatin to preoperative fluoropyrimidine-based chemoradiation and postoperative fluoropyrimidine-based chemotherapy improves disease-free survival in locally...

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Analgesic efficacy and safety of etoricoxib in ear nose throat surgery The aim of this study is to test the analgesic efficacy and safety of etoricoxib (90 mg or 120 mg qd. perioperatively) for post-operative pain relief. The primary endpoint is as follows: (i) does preo...

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A phase II study about interferon gamma 1b to therapy the steroid-refractory bronchiolitis obliterans after allogenic stem cell therapy Objective improvement of lung function, i.e.: • Improvement of SO2, pO2 or pCO2 in oxygen dependent or improvement of FiO2 in ventilated patients ≥ 20 % or • Reduction of oxygen need...

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