A PHASE 2A RANDOMIZED, DOUBLE-BLINDED, DOUBLE DUMMY, PLACEBO AND ACTIVE CONTROLLED, TWO-WAY CROSS-OVER, FLARE-ENRICHED MULTI-CENTRE CLINICAL TRIAL TO EXAMINE THE PAIN RELIEF PRODUCED BY 2 WEEKS OF DAILY ORAL ADMINISTRATION OF A FATTY ACID AMIDE HYDROLASE (FAAH) INHIBITOR PF-04457845 IN PATIENTS WITH OSTEOARTHRITIS OF THE KNEE •To evaluate the efficacy of PF-04457845 (administered QD) versus placebo in relieving pain in patients with osteoarthritis of the knee. •To evaluate the safety and tolerability of PF-04457845 in pati...

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A RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP, MULTI-CENTER STUDY TO INVESTIGATE THE SAFETY AND EFFICACY OF CP-690,550 IN SUBJECTS WITH MODERATE TO SEVERE CROHN’S DISEASE The primary objective is to demonstrate efficacy of CP-690,550 in inducing a clinical response in subjects with moderate-to-severe Crohn’s disease.

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