Trigeminal Nerve Stimulation for Depression: Dose Finding This study will aim to examine the use of external trigeminal nerve stimulation (TNS) as an adjunctive treatment for adults with major depressive disorder (MDD) when added onto antidepress...

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Brain Mechanisms and Targeting Insomnia in Major Depression Preliminary studies suggest that the response to antidepressant medication can be accelerated by targeting insomnia with adjunctive use of eszopiclone. It is not yet known what mechanism(s...

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Biomarkers of Antidepressant Treatment in Adolescents With Major Depression (The Adolescents MDD Study) This study will aim to evaluate the use of Electroencephalography (EEG) biomarkers in adolescent depression. Two specific hypotheses will be tested: H1: Early decreases in prefrontal cord...

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Electroencephalography (EEG) Biomarkers of Response in Depression There are two specific aims of this project: 1. To identify physiologic indicators of venlafaxine treatment response using quantitative EEG (QEEG) cordance, and to determine if cor...

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Neurophysiologic Predictors of Outcome With rTMS Treatment of Major Depressive Disorder Transcranial magnetic stimulation (TMS) therapy has proven to lead to symptom improvement in many individuals with major depressive disorder (MDD), yet there is heterogeneity in outcome, w...

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Biomarkers for Outcomes In Late-life Depression (BOLD) Major depressive disorder (MDD) is a common psychiatric illness with high cost to society and individual patients. One reason for the high cost is that most patients endure lengthy and ult...

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