A Phase I-II Study to Evaluate the Safety, Tolerability and Anti-Disease Activity of the Aminopeptidase Inhibitor, CHR-2797, in Elderly and/or Treatment Refractory Patients with Acute Myeloid Leukaemia or Multiple Myeloma Primary objective(s): • (Phase I) To determine the safety, tolerability, dose-limiting toxicity (DLT) and maximum tolerated dose (MTD) of CHR-2797 when administered orally, once daily, to elderly pati...

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The OPAL Study: A Phase II Single Arm Study to Evaluate the Efficacy, Safety and Tolerability of Tosedostat (CHR-2797) in Elderly Subjects with Treatment Refractory or Relapsed Acute Myeloid Leukemia The primary objective of the study is to evaluate the efficacy of tosedostat in elderly subjects with treatment refractory or relapsed AML by measuring CR and CRp.

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CHROMA THERAPEUTICS CHR-2845-001 : Essai de phase 1 évaluant la tolérance d’un inhibiteur d’histone déacétylase (CHR-2845), chez des patients ayant une hémopathie maligne avancée ou réfractaire aux traitements. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] A phase I study to evaluate the safety and tolerability of the histone deacetylase inhibitor, CHR-2845, in patients with advanced or treatment refractory haematological diseases or lymphoid malignanci...

• Pays France
• Organes Tout cancer hématologique
• Spécialités Thérapies Ciblées