Woman and Man
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Extract
The primary objective of this study is to investigate the safety and efficacy of a fixed dose (150 µg/h, 100 µg/h, or 50 µg/h) over at least 24 hours and up to 48 hours of intravenous BAY 58-2667 in subjects with acute decompensated chronic congestive heart failure needing parenteral pharmacotherapy and invasive hemodynamic monitoring (ie, indwelling pulmonary artery catheter [Swan-Ganz]) and pulmonary capillary wedge pressure (PCWP) ≥ 20 mmHg with CI ≤ 2.5. The primary endpoint will be to evaluate the PCWP reduction at eight hours.
Inclusion criteria
- Acute Decompensated Chronic Congestive Heart Failure (ADHF)