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Effects of the Soluble Mediators of Mastocytes on the Intestinal Epithelial Barrier and of the Enteric Nervous System During the Syndrome of the Irritable Bowel

Update Il y a 4 ans
Reference: NCT00742118

Woman and Man

  • | Country :
  • France
  • | organs :
    • -
  • | Specialty :
    • -

Extract

Patients with irritable bowel syndrome (IBS) have increased intestinal permeability. In addition, mucosal soluble mediators are involved in the pathophysiology of pain in IBS. The investigators aimed to investigate: 1. paracellular permeability in colonic biopsies of IBS patient 2. the ability of soluble factors from colonic biopsies to reproduce in vitro these alterations

Inclusion criteria

  • Irritable bowel syndrome

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