Woman and Man
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Extract
The primary objectives of this study are to assess the effect of high dose NAC (1800 mg): •On small airways by measuring the total and peripheral airway resistance calculated with CFD •On oxidative stress by measuring exhaled NO and oxidative stress markers (CRP, erythrocyte sedimentation rate, glutathione, GPX, SOD, IL-8, IL-6 and 8-isoprostane) in blood and EBC measured at baseline, after 12 weeks of placebo and 12 weeks of NAC.
Inclusion criteria
- Chronic Obstructive Pulmonary Disease