Universal warming protocol

Update Il y a 4 ans
Reference: ISRCTN12342851

Woman Man

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Extract

Background and study aims In order for a woman to become pregnant, the fertilized egg must attach (implant) itself to the lining of the womb. In vitro fertilization (IVF) is a technique used to help people with fertility problems to have a baby. During IVF, couples donate their own sperm and eggs (or use sperm and eggs from a donor). The egg is fertilized by the sperm outside of the body to create an embryo and then returned to the woman’s womb to develop. In many cases, some of the embryos are frozen so that they can be thawed out and used in IVF at a later date (frozen embryo transfer). Current freezing techniques mean that the majority of these embryos survive the freezing process, however scientists are constantly trying to refine these techniques. Embryos are frozen by using ready-to-use freezing solutions. The aim of the study is to assess the effect of various combinations of different brands for freezing/thawing solutions on embryo survival. Who can participate? Infertile women who are undergoing fertility treatments What does the study involve? All participants have eggs removed and fertilized so that embryos can be created. The fertilised embryos are frozen using one of two freezing brand solutions, for later use. Embryos are randomly allocated to one of two groups for freezing and subsequently to one of the two groups for thawing. The embryos are frozen by using ready-to- use freezing solutions made by different commercial brands. These freezing solutions have just slight modification in their composition and it remains to be demonstrated that a thawing solution of a given brand can be used to thaw the embryos frozen with another brand. After the embryos have been thawed, the number that survive the process are recorded. In addition, the number of women who have the embryos implanted who become pregnant is recorded. What are the possible benefits and risks of participating? There are no direct benefits or risks involved with participating Where is the study run from? GynePro Medical (Italy) When is the study starting and how long is it expected to run for? April 2016 to January 2018 Who is funding the study? GynePro Medical (Italy) Who is the main contact? Dr Lodovico Parmegiani


Inclusion criteria

  • Warming cryopreserved human oocytes

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