Woman and Man
- | Country :
- United States
- | organs : -
- | Specialty : -
Extract
Hypothesis 1: Treatment of heart transplant recipients with sildenafil, a PDE-5 inhibitor, will improve small artery elasticity (SAE) when compared to placebo. Hypothesis 2: PDE-5 inhibition will improve endothelial function, resulting in increased production of nitric oxide, reduced activation of circulating endothelial cells, and increased endothelial progenitor cells.
Inclusion criteria
- Cardiac Allograft Vasculopathy