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Kusajili – Clinical trials directory
Result
of your search span> per sponsor: Vertex Pharmaceuticals Incorporated
Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A study in people with cystic fibrosis (a rare hereditary lung disease) to assess the efficacy and safety of two experimental drugs: ivacaftor and VX-661 in combination with ivacaftor
To evaluate the efficacy of VX-661 in combination with ivacaftor and ivacaftor monotherapy through 8 weeks of treatment in subjects with cystic fibrosis (CF) who are heterozygous for the F508del mutat...
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A Clinical Study to evaluate the Safety, Tolerability, and the effects of VX-970 in combination with Chemotherapy on the body in Subjects with Advanced Solid Tumors
-To evaluate the safety/tolerability of intravenous VX-970 administered: Part A – as multiple ascending doses in comb with gem, and with cis/gem in subjects with advanced solid tumors Part B – as mu...
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
Rollover Study of Ivacaftor in Subjects With Cystic Fibrosis and a Non- G551D CFTR Mutation
To evaluate the safety of long-term ivacaftor treatment in subjects with cystic fibrosis (CF)
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A Clinical Study to evaluate the Safety, Tolerability, and the effects of VX-970 on its own and in combination with Carboplatin on the body in Subjects with Advanced Solid Tumors
PART A To determine the maximum tolerated dose (MTD) and evaluate the safety and tolerability of multiple ascending doses of VX 970 administered once weekly (Part A1) or twice weekly (Part A2) as a si...
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A 12-Week, Double-Blind, Randomized, Parallel Group, Placebo-Controlled Study of Two Doses of VX-702 in Subjects with Moderate to Severe Rheumatoid Arthritis
- To define the clinical response to placebo and two doses of VX-702 in subjects with RA using the number of 20% responses as defined by the American College of Rheumatology (ACR20) at Week 12 by appl...
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A study to assess the efficacy and safety of a combination of two experimental drugs in people with cystic fibrosis (a rare hereditary lung disease) Estudio para evaluar la eficacia y seguridad de una combinación de dos farmacos experimentales en personas con fibrosis quística (una enfermedad pulmonar hereditaria rara)
To evaluate the long-term safety and tolerability of VX-661 in combination with ivacaftor in subjects with CF, homozygous or heterozygous for the F508del-CFTR mutation who are in the Treatment Cohort....
Country
None
organs
None
Specialty
None
unknown
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Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A Roll-over study in children with Cystic Fibrosis (a rare hereditary pulmonary disease) to assess the long-term safety and pharmacodynamics of ivacaftor
To evaluate the long-term safety of ivacaftor treatment
Country
None
organs
None
Specialty
None
unknown
More information
Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A Phase 2, Multicenter, Double Blinded, Placebo Controlled Study to Evaluate Safety, Efficacy, Pharmacokinetics, and Pharmacodynamics of VX-661 Monotherapy and VX-661/Ivacaftor Cotherapy in Subjects with Cystic Fibrosis, Homozygous or Heterozygous for the F508del CFTR Mutation
-To evaluate the safety and tolerability of VX-661 monotherapy and VX-661/VX-770 cotherapy -To evaluate the effect of VX-661 monotherapy and VX-661/VX-770 cotherapy on CFTR function
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A study in people with Cystic Fibrosis ( a rare hereditary pulmonary disease) to assess the efficacy and safety of a combination of two experimental drugs Uno studio condotto in pazienti con fibrosi cistica (una rara malattia ereditaria polmonare) per valutare l'efficacia e la sicurezza di una combinazione di due farmaci sperimentali
To evaluate the efficacy of lumacaftor in combination with ivacaftor through Week 24 in subjects with Cystic Fibrosis who are homozygous for the F508del-CFTR mutation Valutazione dell'efficacia ...
Country
None
organs
None
Specialty
None
Closed trial
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Woman and Man Max 99 years
Vertex Pharmaceuticals Incorporated
Update Il y a 5 ans
A Phase 2 Rollover Protocol of Telaprevir (VX-950) in Combination with Peginterferon Alfa-2a (Pegasys®) and Ribavirin (Copegus®) in Subjects Enrolled in the Control Group (Group A) of Study VX06-950-106, VX05-950-104 and VX05-950-104EU Who did not Achieve or Maintain an Undetectable HCV RNA Level Through Sustained Viral Response
To provide access to a telaprevir-based treatment to subjects enrolled in the Peg IFN alfa-2a plus ribavirin Control Group (Group A) of Studies VX06 950-106 (Study 106), VX05-950-104 (Study 104) or VX...
Country
None
organs
None
Specialty
None
Closed trial
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