Evaluation of Safety and Efficacy of Artemether-Lumefantrine Tablets in African Infants and Children With Uncomplicated P. Falciparum Malaria This study will assess the safety and efficacy of artemether-lumefantrine tablets (6-dose regimen) in African infants / children with acute uncomplicated falciparum malaria.

• Country Kenya, Nigeria, Tanzania, United Republic of
• organs None
• Specialty None

Improved Clinical and Microscopy Diagnosis at Primary Health Care in Tanzania General objective: To improve the quality of fever case management in children in government health facilities in Tanzania Hypothesis:The training of health workers, as well as provision, ...

• Country Tanzania, United Republic of
• organs None
• Specialty None

Acute HIV Infection Observational Study The purpose of this study is to collect data and body fluid samples from people with acute or established HIV infection and from HIV uninfected people. Data from this study will be used to...

• Country Malawi, South Africa, Tanzania, United Republic of, Uganda, United States
• organs None
• Specialty None

Evaluating Strategies to Reduce Mother-to-Child Transmission of HIV Infection in Resource-Limited Countries The purpose of this study is to examine effective methods of preventing the transmission of HIV from mother to child during pregnancy, labor and delivery, and breastfeeding. This is one pa...

• Country India, Malawi, South Africa, Tanzania, United Republic of, Uganda, Zambia, Zimbabwe
• organs None
• Specialty None

Effects of intestinal helminth infections in early childhood on immune response, inflammation, anaemia and malnutrition Not provided at time of registration

• Country Tanzania, United Republic of
• organs None
• Specialty None

Safety And Immunogenicity Of Novel Candidate Blood-Stage Malaria Vaccine P27A : Phase Ia/Ib P27A study is designed as a randomized phase Ia/Ib trial to evaluate the safety and immunogenicity of the blood stage candidate vaccine P27A against P. falciparum - P27A antigen and associ...

• Country Switzerland, Tanzania, United Republic of
• organs None
• Specialty None

Tuberculosis and Human Immunodeficiency Virus (HIV) Immune Reconstitution Syndrome Trial (THIRST) The purpose of this study is twofold: (1) to assess the feasibility and safety of fixed dose combination zidovudine/lamivudine/abacavir in HIV infected subjects with tuberculosis in a reso...

• Country Tanzania, United Republic of
• organs None
• Specialty None

Evaluating the Safety of Immediate Versus Deferred Isoniazid Preventive Therapy Among HIV-Infected Pregnant Women Tuberculosis (TB) is a leading cause of death among HIV-infected persons in low-income settings and can be a serious complication for HIV-infected pregnant women and their infants. Isoniaz...

• Country Botswana, Haiti, India, South Africa, Tanzania, United Republic of, Thailand, Uganda, Zimbabwe
• organs None
• Specialty None

Determining Characteristics and Behaviors of Adolescent Women Regarding HIV Risk and Microbicide Trial Participation This study will examine characteristics and behaviors of young women in India and Tanzania to determine which challenges and opportunities exist for conducting future trials of HIV prevent...

• Country Tanzania, United Republic of
• organs None
• Specialty None

A Randomized, Comparative Study of Daily Dapsone and Daily Atovaquone for Prophylaxis Against PCP in HIV-Infected Patients Who Are Intolerant of Trimethoprim and/or Sulfonamides To compare the efficacy and safety of dapsone versus atovaquone in preventing or delaying the onset of histologically proven or probable Pneumocystis carinii pneumonia in HIV-infected pati...

• Country Tanzania, United Republic of, United States
• organs None
• Specialty None