Intravenous RPR109881 in Male or Female Patients With Advanced Breast Cancer Who no Longer Respond to Anthracycline, Taxane and Capecitabine Treatment The purpose of this clinical trial is to determine if the investigational drug is able to reduce/shrink advanced breast cancer tumors in patients who no longer benefit from anthracyclines,...

• Country Argentina, Belgium, Canada, Colombia, Denmark, France, Germany, Italy, Korea, Republic of, Netherlands, South Africa, Spain, Switzerland, Turkey, United States
• organs None
• Specialty None

A Study to Evaluate the Safety and Efficacy of ASP015K in Moderate to Severe Rheumatoid Arthritis Subjects Who Have Had an Inadequate Response to Methotrexate The purpose of this study is to evaluate the safety and efficacy of ASP015K in moderate to severe rheumatoid arthritis subjects who are methotrexate-inadequate responders (MTX-IR).

• Country Belgium, Bulgaria, Colombia, Czech Republic, Hungary, Mexico, Poland, United States
• organs None
• Specialty None

A Study to Evaluate the Effect of ASP1941 in Adult Patients With Type 2 Diabetes Mellitus Evaluate the efficacy, safety, and tolerability of multiple doses of ASP1941 compared to placebo over 12 weeks of therapy in adult patients with type 2 diabetes mellitus.

• Country Colombia, India, Mexico, Philippines, United States
• organs None
• Specialty None

A Study Evaluating the Gastrointestinal (GI) Safety and Tolerability of Aliskiren Compared to Ramipril in Essential Hypertension This study will evaluate the long-term gastrointestinal (GI) safety and efficacy of aliskiren (300 mg) compared to ramipril (10mg) in patients ≥ 50 years with essential hypertension.

• Country Argentina, Colombia, France, Germany, India, Spain, United States
• organs None
• Specialty None

Evaluating Efficacy of Canakinumab (ACZ885) in Prevention of Acute Flares in Chronic Gout Patients Initiating Allopurinol Therapy A 24-week, dose-ranging, multi-center, double-blind, double-dummy, active-controlled study to evaluate canakinumab (ACZ885) for prophylaxis of signs and symptoms of acute flares in chronic...

• Country Argentina, Belgium, Colombia, Czech Republic, Germany, Guatemala, Hungary, Poland, Portugal, Russian Federation, Singapore, Slovakia, South Africa, Spain, Taiwan, Province of China, Turkey, United Kingdom, United States
• organs None
• Specialty None

An Effectiveness and Safety Study of Intravenous Golimumab in Patients With Active Rheumatoid Arthritis Despite Treatment With Methotrexate Therapy The purpose of this study is to evaluate clinical effectiveness and safety of golimumab with methotrexate (MTX) in the treatment of rheumatoid arthritis (RA) when compared to MTX alone.

• Country Argentina, Australia, Colombia, Hungary, Korea, Republic of, Lithuania, Malaysia, Mexico, New Zealand, Poland, Russian Federation, Ukraine, United States
• organs None
• Specialty None

Efficacy and Safety of Enteric-coated Mycophenolate Sodium in Combination With Two Corticosteroid Regimens for the Treatment of Lupus Nephritis Flare The study will investigate the efficacy and safety of enteric-coated mycophenolate sodium in combination with two different corticosteroid (CS) regimes for the induction of remission of a ...

• Country Colombia, France, Germany, Greece, Hungary, Italy, Spain, Taiwan, Province of China, United Kingdom
• organs None
• Specialty None

A Study to Assess the Effect of QAW039 in Non-atopic Asthmatic Patients The purpose of the study was to assess the clinical effect of QAW039 in non-atopic asthmatics taking low dose Inhaled Corticosteroid (ICS) as background therapy.

• Country Belgium, Colombia, Czech Republic, Germany, India, Korea, Republic of, Poland, Romania, South Africa, United States
• organs None
• Specialty None

Efficacy of Clonidine and Propranolol in Dentistry (AAA) The aim of the study is to determine the efficacy of clonidine and propranolol for transient anxiety management and intra and postoperative pain in patients undergoing ambulatory surgery o...

• Country Colombia
• organs None
• Specialty None

Irinotecan in Patients With Advanced Metastatic Breast Cancer Who Have Experienced Failure of an Anthracycline, a Taxane, and Capecitabine The purpose of this phase II, randomized, open-label clinical trial is to study 2 schedules of single-agent Irinotecan in women with metastatic breast cancer who have experienced failure o...

• Country Argentina, Australia, Colombia, New Zealand, United States
• organs None
• Specialty None