The Effects of Inorganic Nitrite on skeletal muscle: Physiology, Pharmacology and Therapeutic Potential in patients suffering from Intermittent Claudication

Update Il y a 4 ans
Reference: EUCTR2012-000201-72

Woman and Man

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Extract

Primary objective: to determine the effect of inorganic Sodium Nitrate (daily dose of 7mmol) for six weeks compared to placebo in respect of: 1) treadmill absolute walking distance. 2) and quality of life in patients with stable intermittent claudication and in a subgroup of 20 patients: 4) Skeletal muscle perfusion will be assessed using MRI 5) Skeletal muscle biopsies will be taken to assess mitochondrial function


Inclusion criteria

  • Peripheral arterial disease

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