Attenuation of haemodynamic response to tracheal intubation with oral gabapentin and midazolam in breast cancer patients

Mise à jour : Il y a 4 ans
Référence : ISRCTN15943548

Femme Homme

  • | Pays :
  • -
  • | Organes :
  • -
  • | Spécialités :
  • -

Extrait

Background and study aims A modified radical mastectomy is a procedure in which the entire breast is removed in order to remove breast cancer. A flexible plastic tube is placed into the trachea (windpipe) to keep the airway open (tracheal intubation). The aim of this study is to find out whether the drugs midazolam and gabapentin can reduce the stress response (increased heart rate and blood pressure) to tracheal intubation. Who can participate? Patients aged between 18 and 65 undergoing modified radical mastectomy What does the study involve? Participants are randomly allocated into two groups. One group is given oral gabapentin and midazolam 90 minutes before intubation. The other group is given gabapentin 90 minutes before intubation. Heart rate, blood pressure, sedation and side effects are measured to see whether gabapentin and midazolam can reduce the stress response to tracheal intubation. What are the possible benefits and risks of participating? The results of this study will increase scientific knowledge and may benefit future patients. Where is the study run from? National Cancer Institute, Cairo University (Egypt) When is the study starting and how long is it expected to run for? February to June 2017 Who is funding the study? National Cancer Institute, Cairo University (Egypt) Who is the main contact? Dr Ahmed Bakir [email protected]


Critère d'inclusion

  • Modified radical mastectomy under general anaesthesia

Liens