Woman and Man
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Extract
The primary objectives are: 1) To establish the dose-response relationship of MOA-728 by observing spontaneous bowel movements, and to establish appropriate doses to take into confirmatory phase 3 studies. 2) To evaluate the safety, and tolerability of oral MOA-728 given daily in a population of subjects with chronic, non-malignant pain who have opioid-induced bowel dysfunction.
Inclusion criteria
- Opioid-induced bowel dysfunction