Extrait

To demonstrate the efficacy of MR308 doses in the Treatment of acute moderate to severe pain. Efficacy will be assessed by showing superiority of MR308 doses over Placebo and non-inferiority compared with Tramadol, followed by superiority over Tramadol based on teh sum of pain intesity differences over 0-4 hours (SPID4).

Critère d'inclusion

• Acute pain after third molar tooth extraction; dental procedure must have involved extraction of at least two impacted third molars requireing bone removal. If only two impacted third molars are extracted, they must be ipsilateral and both required bone removal under local anaesthesia

Liens

• euctr