Extrait

Background and study aims Chronic obstructive pulmonary disease (COPD) is the name used to refer to a number of progressive devastating and debilitating lung diseases, which includes chronic bronchitis, emphysema and chronic obstructive airways disease. People that have COPD typically feel breathless after physical activity, have a persistent cough with phlegm and suffer frequently from chest infections. Feeling short of breath can lead to inactivity and muscle deconditioning in patients with COPD. Positive airway pressure (PAP) can relieve shortness of breath and improve exercise tolerance (the amount of exercise that they are able to do). This study examines the effect of PAP delivered by a battery powered handheld device to COPD patients after exercise to relieve shortness of breath. Who can participate? Aged at least 18 with diagnosed COPD but able to do mild exercise. What does the study involve? Participants are randomly allocated into one of three groups. They are all then asked to do some mild exercise. Those in group 1 are then provided with the portable PAP device to use after the exercise to ease breathlessness. Those in group 2 are provided with what looks like a portable PAP device, but it is nonfunctional (a SHAM device) to use after the exercise. Those in group 3 are asked to perform lip breathing after exercise. The time it takes to return to the shortness of breath experienced prior to exercise for each participant is determined. We anticipate that the time after exercise to return to baseline shortness of breath using the hand held device is shorter than that while using a SHAM device and pursed-lip breathing (PLB) after exercise. As a secondary outcome, we will evaluate the distance walked during exercise. What are the possible benefits and risks of participating? Other than possibly gaining a better understanding of their ability to exercise and contributing to general knowledge of strategies to address shortness of breath, participants will not benefit directly from enrolling in the study. Risks of study participation include breathing and general discomfort while exercising. Lung damage from the portable positive airway pressure device is a remote possibility. Participants will be closely monitored during exercise and may request that the exercise activity be terminated. Patients with a history of lung damage from positive pressure devices are not eligible to participate. Where is the study run from? Pittsburgh Pulmonary Associates Ltd (USA) When is the study starting and how long is it expected to run for? April 2014 to October 2015 Who is funding the study? Philips Respironics (USA) Who is the main contact? Mr William Hardy [email protected]

Critère d'inclusion

• Chronic Obstructive Pulmonary Disease

Liens

• isrctn
• ictrp