Extrait

According to estimations, Alzheimer's disease affects approximately 860,000 people aged of more than 65 years in France. This disease is characterized by disorders of cognitive functions, including memory, associated with structural and functional modifications of the brain. These changes are evolving within the pathology progression and can be evaluated with neuropsychological tests (to assess capabilities such as language, orientation, etc.) and also with brain imaging (e.g. MRI). Alzheimer's disease is still poorly understood, nevertheless currently available treatments can slow its development if the disease is diagnosed early enough. Thus, the objective is to identify markers for early diagnosis of Alzheimer's disease, to better describe the evolution of this disease. The three main objectives of this project are - to identify, compare and combine predictive markers of Alzheimer's disease - to make a significant contribution to the understanding of the pathophysiological mechanisms of Alzheimer's disease - to study the ability of different neuroimaging techniques to follow the evolution of this pathology.

Critère d'inclusion

• Alzheimer's disease

Liens

• nct
• ictrp