Extract

Patients with positive margins after surgery for cervical intraepithelial neoplasia (CIN) II/III are at increased risk for residual/recurrent disease. There is no accepted treatment regimen to reduce the number of recurrent/persistent disease. Various studies showed the efficacy of acetyl salicylic acid as chemopreventive agent and treatment option for cancer and its precursors. With respect to cervical dysplasia cyclooxygenase inhibitors, such as acetyl salicylic acid, were shown to be promising for the treatment of CIN. Acetyl salicylic acid is expected to reduce the rate of recurrent/persistent disease after surgery for CIN II/III with positive margins. Primary outcome parameters: To evaluate whether or not a treatment with acetyl salicylic acid 100mg/day reduces the rate of recurrent/persistent disease after surgery for CIN II/III with positive margins during a 6-month treatment period.

Inclusion criteria

• Cervical intraepithelial neoplasia grade II/III with positive margin after surgery

Links

• ictrp
• euctr