Femme et Homme
- | Pays : -
- | Organes : -
- | Spécialités : -
Extrait
• To estimate the minimum (trough) pertuzumab concentration (Cmin) at Day 43 for two dose levels of pertuzumab in order to identify a dose that produces a steady-state Cmin of ≥ 20 μg/mL in 90% of patients receiving pertuzumab and trastuzumab plus chemotherapy as first-line treatment for HER2-positive inoperable locally advanced or recurrent and/or metastatic adenocarcinoma of the stomach or gastroesophageal junction • To evaluate the safety and tolerability of two dose levels of pertuzumab in combination with trastuzumab and chemotherapy administered every 3 weeks to patients with HER2-positive inoperable locally advanced or recurrent and/or metastatic adenocarcinoma of the stomach or gastroesophageal junction
Critère d'inclusion
- HER2-positive adenocarcinoma of the stomach or gastroesophageal junction