A trial comparing the efficacy between the two hormone drugs degarelix and triptorelin in patients having not yet entered the menopause and having not undergone surgery. Additional to each treatment the patients receive letrozole for locally advanced endocrine responsive breast cancer

To evaluate the endocrine activity of neoadjuvant letrozole plus either degarelix or triptorelin.

Premenopausal patients with histologically confirmed locally advanced breast cancer and with primary tumor of ER+/PgR+ and HER2 negative or not amplified

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