Extrait

Background and study aims In order for a woman to become pregnant, the fertilised egg must attach (implant) itself to the lining of the womb. In vitro fertilisation (IVF) is a technique used to help people with fertility problems to have a baby. During IVF, couples donate their own sperm and eggs (or use sperm and eggs from a donor). The egg is fertilised by the sperm outside of the body to create an embryo and then returned to the woman’s womb to develop, approximately three days later (fresh embryo transfer). Although IVF has become more and more successful in recent years, there is still a relatively high failure rate. In many cases, some of the embryos are frozen so that they can be thawed out and used in IVF at a later date (frozen embryo transfer). The aim of this study is to find out the effectiveness and cost-effectiveness of using frozen embryo transfer three months after egg donation, compared to fresh embryo transfer, and whether the technique used has an effect of the health of the baby at birth. Who can participate? Couples undergoing their first found of IVF fertility treatment at fertility centres in the UK. What does the study involve? Couples are randomly allocated to one of two groups. At the start of the study, all participants donate sperm and eggs so that embryos can be created. For participants in the first group, three days after egg donation, the fertilised embryos are placed in the female participants’ womb. For participants in the second group, the fertilised embryos are frozen, for later use. These embryos are then thawed three months after the egg donation and implanted into the female participants’ womb. Women in both groups are monitored to find out how many become pregnant. For those who do, the health of the baby is assessed by the medical team at the time of birth. What are the possible benefits and risks of participating? There are no immediate direct benefits of taking part in the study, but participating will help to inform future fertility treatment in the UK. There are no additional risks to the standard risks involved with IVF. Where is the study run from? Twelve fertility units in the Scotland and England (UK). When is the study starting and how long is it expected to run for? March 2015 to February 2019 Who is funding the study? National Institute for Health Research (UK) Who is the main contact? 1. Ms Christina Cole (public) [email protected] 2. Dr Abha Maheshwari (scientific) [email protected]

Critère d'inclusion

• Infertility

Liens

• ictrp
• isrctn