Extrait

Background and study aims The rapid and reliable identification of cognitive (thinking) changes has become more urgent as patients are presenting earlier with subjective memory loss and milder memory impairments. Early detection is therefore increasingly important for planning the clinical management of these diseases along with the use of protective strategies. The influence of early patterns of cognitive deficits and regional brain dysfunction on the development of behavioural symptoms in patients with dementia and stroke hasn’t been extensively studied. Early prediction of potential symptoms and their causes will improve the management of such patients. We aim to assess changes in smaller patient groups to find what determines response and non-response to treatment and better inform clinical practice. This study will establish local norms for cognitive tests and compile a database of assessments of patients with degenerative and vascular brain disease Who can participate? Volunteers aged over 18 with no history of neurological or psychiatric disorders, and patients aged over 18 who experience cognitive change as a result of neurodegenerative disease, vascular brain disease or dementia due to other causes. What does the study involve? The study is undertaken over a 5-year period. Patients are tested every 6 months and the progression of cognitive deficits is monitored to find patterns to identify the different forms of dementia, monitor the formation/development of abnormal beliefs, and assess and monitor the effects of non-drug treatments. What are the possible benefits and risks of participating? Not provided at time of registration Where is the study run from? Royal Hallamshire Hospital Neuropsychology Clinic (UK) When is the study starting and how long is it expected to run for? February 2013 to February 2018 Who is funding the study? National Institute for Health Research (NIHR) (UK) Who is the main contact? Dr Katija Khan [email protected]

Critère d'inclusion

• Topic: Dementias and Neurodegenerative Diseases Research Network; Subtopic: Dementia; Disease: Dementia

Liens

• ictrp
• isrctn