Femme et Homme
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Extrait
Part I of the study: - to describe the pharmacokinetics (PK) and maximum tolerated dose (MTD), if achieved, of RO5083945 in patients with metastatic and/or locally advanced malignant EGFR+ solid tumors Part II of the study: - to investigate the Tumor Growth Control Rate (TGCR): CR, PR and stable disease (SD) > 2 months and safety profile of RO5083945 in patients with metastatic and/or locally advanced colorectal cancer expressing EGFR and mutant KRAS
Critère d'inclusion
- Parte I: Tumores sólidos malignos metastáticos y/o localmente avanzados que expresan el receptor del factor de crecimiento endotelial (EGFR) Parte II: Cáncer colorrectal metastático o localmente avanzado con expresión de EGFR y del homólogo del oncogén viral del sarcoma 2 de rata Kirsten (KRAS) mutante,Part I: Metastatic and/or locally advanced malignant solid tumors expressing (EGFR) Part II: Metastatic or locally advanced colorectal cancer expressing (EGFR) and mutant (KRAS)