Contraction (Exercise) Mediated Glucose Uptake as a Therapeutic Target in Type 2 Diabetes The purpose of this project is to determine whether glucose metabolism can be improved by administering a substance (nitric oxide donor) normally released by muscles during exercise.

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Type 2 Diabetes and Exercise - A Pilot Study A randomised, cross-over trial targeting a small sample of older (age 45-65 years) overweight adults with type 2 diabetes the aims of this pilot study are to: 1. Determine the feasibili...

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The Effects of Metformin on Functional Capacity in Individuals With Peripheral Artery Disease-Related Intermittent Claudication The purpose of this study is to determine the effects of metformin on functional capacity (pain-free and maximum walking times) in individuals with peripheral artery disease (PAD)-related ...

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The Effect of Alcohol on ABCA1 Expression and Lipid Metabolism The purpose of this study is to investigate the effects of red wine on ABCA1 levels

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Effects of Heart Rate Reduction on Central Arterial Pressure in Healthy Individuals The purpose of this project is to determine the effects of slowing heart rate upon both central and peripheral blood pressures using Ivabradine. The effects of Ivabradine will be compared ...

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The Effects of Ramipril on Clinical Symptoms in Patients With Peripheral Arterial Disease One important clinical challenge in older individuals is maintaining mobility in the absence of pain. Peripheral arterial disease affects up to 12% of adults over 50 and impairs quality of...

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Angiotensin Converting Enzyme Inhibitors in Marfan Syndrome The purpose of this research is to assess the effects of a drug called perindopril on the aorta in people known to have Marfan Syndrome. The aorta is the major artery of the body that come...

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Angiotensin Converting Enzyme (ACE) Inhibition and Peripheral Arterial Disease Leg pain caused by peripheral arterial disease (PAD) can severely impede walking ability. Our preliminary findings indicate that the drug ramipril is much more effective in improving walki...

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Improving Metabolism With HDL Cholesterol High levels of good cholesterol (HDL) in our blood decreases our chance of having a heart attack. This relates in part to the role good cholesterol plays in reducing build up of fat in the...

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