Effect of exercise on lipid challenged insulin resistance and cardiovascular risk markers in PolyCystic Ovary Syndrome (PCOS) Background and study aims Polycystic ovary syndrome (PCOS) is commonly associated with obesity, high levels of free fatty acids and insulin resistance (a condition in which the body produces insulin,...

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Soy isoflavones on markers of bone turnover in females in the early menopause Background and study aims: Soy (a vegetable foodstuff) contains chemicals called phyto-oestrogens (isoflavones) that have been shown to be of potential benefit to people during menopause as soy can al...

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Study to investigate weight loss using “virtual gastric band” hypnotherapy compared to “relaxation” hypnotherapy and following a self directed diet Background and study aims In the UK it has been reported that 1 in 4 UK adults are obese and a further about 4 in 10 of men and 3 in 10 women are overweight. Excess weight is an increasing problem bot...

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Effect of lowering fatty acids levels with acipimox treatment on post-meal fat levels and insulin resistance in women with polycystic ovary syndrome and diabetes compared to healthy subjects Background and study aims Type 2 diabetes mellitus (type 2 DM) is well known to be associated with increased risks of high blood pressure, angina, heart attack and stroke. Polycystic ovary syndrome (P...

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A double-blind, placebo-controlled, crossover trial of soy phytoestrogens in patients with compensated hypothyroidism Not provided at time of registration

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Aspartame study: Determination of the symptoms of aspartame in subjects who have reported symptoms in the past compared to controls Background and study aims There is public concern over the safety of the artificial sweetener aspartame and the European Food Safety Authority has brought together an expert committee to review the ev...

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Effect of chocolate with and without polyphenols on health in type 2 diabetes Not provided at time of registration

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Short term effects of high polyphenol content chocolate on blood vessel health Background and study aims Dark chocolate rich in polyphenols (mainly epicatechin, a bitter compound) can reduce the risk of heart disease. The earliest signs of heart disease are thought to be linked...

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Biological variation of insulin resistance, testosterone and cardiovascular risk factors in women with polycystic ovary syndrome: modification with rimonabant compared to metformin Not provided at time of registration

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The effect of Roux-en-Y bariatric surgery on early and late cardiovascular risk markers in patients with obesity Not provided at time of registration

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