Study to evaluate the efficacy and safety of givinostat in ambulant patients with Duchenne Muscular Dystrophy. Estudio para evaluar la eficacia y la seguridad de givinostat en pacientes ambulantes con distrofia muscular de Duchenne (DMD) To establish the effects of givinostat versus placebo administered chronically over 18 months to slow disease progression in ambulant DMD subjects Establecer los efectos de givinostat en compara...

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Multicenter, randomized, double-blind, placebo-controlled study to evaluate the effect of ITF2357 on mucosal healing in patients with moderate-to-severe active Crohn’s Disease To determine the ability of ITF2357 to induce complete healing of mucosal ulcerations of ileum and/or colon, assessed by endoscopy

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An Open-Label Extension of the Dose Finding study (DSC/08/2357/36) in patients with polyarticular course Juvenile Idiopathic Arthritis (poly JIA) The purpose of this extension study is to determine the safety of Givinostat in a long term treatment of patients who participated in DSC/08/2357/36 study with good results (clinical benefit al least ...

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Pharmacokinetics, pharmacodynamics and safety of a new Leuprolide acetate 22.5 mg depot formulation, when given as palliative treatment to prostate cancer patients Part A: preliminary investigation of the safety, pharmacodynamics and pharmacokinetics of a new leuprolide acetate depot 3-month formulation after i.m. or s.c. administration to patients with prostate...

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A randomized, double-blind, placebo-controlled, parallel group multicenter study to investigate efficacy and safety of ITF 2357 in the management of patients with active moderate to severe Crohn’s disease To identify one or more effective doses of ITF 2357 in the management of Crohn’s disease suitable for further evaluation in phase III studies

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Acromegalia acromégalie To investigate the effect of treatment on GH and IGF-1 concentrations. Étudier l’effet du traitement sur les concentrations de GH et d’IGF-1

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A multicenter, open label, dose finding study to evaluate efficacy and safety of Givinostat administered in two different doses in patients with polyarticular course Juvenile Idiopathic Arthritis (poly JIA) not adequately responding to the standard treatment To evaluate the efficacy of Givinostat administered in two different doses to patients with polyarticular course JIA not adequately responding to the standard treatment, to the purpose of selecting th...

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