PHASE II RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED MULTICENTER EFFICACY AND SAFETY STUDY OF TANEZUMAB AS ADD-ON THERAPY TO OPIOID MEDICATION IN PATIENTS WITH PAIN DUE TO BONE METASTASES The primary objective of this study is to evaluate the analgesic efficacy of single dose tanezumab 10 mg in combination with opioids (tanezumab 10 mg + opioids compared with opioids alone (placebo + o...

• Country None
• organs None
• Specialty None

A trial to investigate the efficacy and safety of treatment with RN6G in patients with age related macular degenerateion resulting in age-related loss of central vision To determine the efficacy of RN6G in subjects with geographic atrophy in the study eye.

• Country None
• organs None
• Specialty None

Study to assess the safety, tolerability, and efficacy of PF-05212384 in combination with chemotherapy in patients with metastatic colorectal cancer Evaluar la seguridad , tolerabilidad, y eficacia de la combinación de PF-05212384 más quimioterapia en pacientes con cáncer colorrectal metastásico Phase 1b: -To assess safety and to determine the maximum tolerated dose (MTD) and recommended Phase 2 dose (RP2D) of the combination of PF-05212384 plus FOLFIRI in patients treated at non-Japanese cli...

• Country None
• organs None
• Specialty None

A long term safety study of pregabalin in children and adults 1 month -65 years of age for add-on epilepsy treatment To evaluate the long term safety and tolerability of pregabalin in pediatric subjects 1 month through 16 years of age with partial onset seizures and pediatric and adult subjects 5 to 65 years of age ...

• Country None
• organs None
• Specialty None

A LONG-TERM, OPEN-LABEL EXTENSION STUDY OF TOFACITINIB (CP-690,550) FOR THE TREATMENT OF PSORIATIC ARTHRITIS • To evaluate the long term safety and tolerability of treatment with tofacitinib (5 mg twice daily [BID] and 10 mg BID) in adult subjects with active Psoriatic Arthritis (PsA).

• Country None
• organs None
• Specialty None

Study Evaluation of the Long Term Safety and Clinical Benefit of Etanercept In 3 Sub-types of Childhood Arthritis To monitor the occurrence of malignancy in pediatric subjects with extended oligoarticular JIA, ERA, or PsA.

• Country None
• organs None
• Specialty None

Investigation of Early Structural Changes in Patients with Anklosing Spondyloarthritis The primary objective of this study is to compare the efficacy of ETN against placebo in improving symptoms of early non-radiographic axial SpA at 12 weeks when added to a background NSAID at the opti...

• Country None
• organs None
• Specialty None

A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP, 10-WEEK PLACEBO CONTROLLED FIXED DOSE STUDY OF PD 0332334 AND PAROXETINE EVALUATING THE EFFICACY AND SAFETY OF PD 0332334 FOR THE TREATMENT OF GENERALIZED ANXIETY DISORDER • To assess the efficacy of PD 0332334 in the treatment of GAD as measured by the change from Baseline in the HAM-A total score at Week 8. • To assess the safety and tolerability of PD 0332334 in su...

• Country None
• organs None
• Specialty None

A Phase 2B, Randomized, Double-Blind, Placebo-Controlled Study to Evaluate the Safety and Efficacy of Staphylococcus Aureus 4-Antigen Vaccine (SA4Ag) in Adults Undergoing Elective Posterior Instrumented Lumbar Spinal Fusion Procedures Primary Efficacy Objective To assess the efficacy of SA4Ag in the prevention of postoperative S. aureus BSI and/or deep incisional or organ/space SSI occurring within 90 days of elective posterior ins...

• Country None
• organs None
• Specialty None

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY TO EVALUATE THE EFFICACY AND SAFETY OF 12-WEEK ADMINISTRATION OF PF-00734200 TO SUBJECTS WITH TYPE 2 DIABETES MELLITUS AND INSUFFICIENT GLYCEMIC CONTROL ON METFORMIN TREATMENT To evaluate the effect of two oral doses of PF-00734200 on change from baseline to 12 weeks in HbA1c levels in subjects with T2DM on metformin.

• Country None
• organs None
• Specialty None