A study to assess the safety and immunogenicity of an anti leukemia Antigen-Specific Cancer Immunotherapeutic (ASCI) combined with infusions of T lymphocytes in in vivo regulatory T cells depleted patients as post-consolidation therapy for adult patients with WT1-positive Acute Myeloid Leukemia (AML) Co-primary Objectives : To evaluate the safety of combined treatment strategy of WT1-A10 + AS01B, infusions of ex vivo regulatory T cells depleted T lymphocytes and in vivo regulatory T cells deplet...

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Influence of a new model of relative hypoxia on the evolution of erythropoietin and haemoglobin in patients undergoing breast reconstruction by a Deep Inferior Epigastric Perforator Flap Impact of differents models of relative hypoxia on the erythropoietin, erythrocyte and haemoglobin levels.

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A phase II study of doxorubicin, cyclophosphamide and vindesine with valproic acid in patients with refractory or relapsing small cell lung cancer after platinum derivatives and etoposide To determine 6 months progression-free survival of the combination of doxorubicin, cyclophosphamide and vindesine (VdsAC) plus valproic acid in patients with refractory SCLC after treatment with plati...

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Étude KIARA : étude de phase 2 visant à déterminer le bénéfice clinique du trastuzumab emtansine chez des patientes ayant un cancer du sein positif pour HER2 métastatique avec des métastases cérébrales. Le cancer du sein prend naissance dans les cellules du sein mais il peut aussi envahir les tissus voisins et former des métastases dans d’autres parties du corps. La surexpression de HER2 est liée à d...

• Pays France
• Organes Sein
• Spécialités Immunothérapie - Vaccinothérapie, Imagerie

Neoadjuvant Biomarker ResearcH Study of Palbociclib Combined with Endocrine Therapy in Estrogen Receptor Positive/ HER2 Negative Breast CAncer • To identify biomarkers of resistance to a 4-month preoperative treatment of palbociclib plus endocrine therapy defined as stable or progressive disease by ultrasound (based on WHO criteria) using RN...

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Imaging of head and neck tumors and their associated lymph nodes after intravenous injection of Indocyanine Green, a fluorescent molecule Definition of the distribution of intravenously injected ICG in the normal and pathological lymph nodes draining the dissected tumor in head and neck cancer patients or in nodes recurrences in head an...

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Randomised Phase II study of biweekly versus fractionated triweekly combination Taxotere-Cisplatin-5FU in advanced gastric and gastro-esophageal junction cancer evaluate toxicity of a biweekly and a fractionated triweekly regimen of Taxotere-Cisplatin-5FU in advanced gastric and oesogastric junction cancer

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A non randomized , stratified phase II trial evaluating efficacy and safety of oxaliplatin in combination with 5-Fluorouracil in patients with platinum-sensitive and platinum-resistant recurrent ovarian carcinoma to assess objective response rate

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The use of isotope-bound antibodies to visualize and subsequently treat B-cell lymphoma Evaluation of safety of Zirconium-89 (89Zr)- rituximab chimeric anti-CD20 antibody for PET/CT imaging and dosimetry. Evaluation of safety of Yttrium-90 (90Y)-rituximab chimeric anti-CD20 antibody radi...

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A study evaluating the effect of a chemotherapy regimen on the menstrual and ovarian functions of young breast cancer patients - Evaluate the impact of a cyclophosphamide-free regimen on the ovarian function recovery defined as menstrual resumption within 12 months following the end of chemotherapy - Evaluate the impact of a ...

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