Short-term growth study in children with asthma treated with fluticasone propionate / formoterol spray (flutiform®). Undersøgelse af korttidsvækst hos børn med astma i behandling med fluticasonpropionat /formoterol spray (flutiform®) •To show non-inferiority of flutiform pMDI 50/5 µg (2 puffs bid) versus fluticasone pMDI 50 µg (2 puffs bid) based on the mean lower leg growth rates.

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A study which will show the equivalence in analgesic efficacy and bowel function taking oxycodone equivalents of 120 and 160 mg per day as achieved with the higher OXN PR tablet strengths (OXN60/30 mg PR, OXN80/40 mg PR) twice daily compared to the identical daily dose taken as a combination of lower tablet strengths in subjects with non-cancer or cancer pain that requires around-the-clock opioid therapy Primary objective: To demonstrate equivalence between multiple lower strength OXN PR tablets and a single higher strength OXN PR tablet taken at the same overall total daily dose as shown by: • Anal...

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not applicable The aim of this study is to investigate the efficacy and safety of OXN PR in the treatment of BPS and to further support the evidence for the use of opioids in this indication. The main objective is ...

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A randomised, double-blind, placebo-controlled, parallel group, multicenter study to evaluate the long-term efficacy and safety of Norspan® versus placebo Norspan in subjects with chronic, moderate to severe osteoarthritis pain of the hip and/or knee To evaluate the long-term efficacy and safety of Norspan® versus placebo Norspan in subjects with chronic, moderate to severe osteoarthritis pain of the hip and/or knee.

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An open label, multi-centre, prospective age-group-controlled study to evaluate efficacy and safety of buprenorphine transdermal patches in subjects with chronic, moderate to severe osteoarthritis pain of the hip and/or knee Evaluate the efficacy of buprenorphine transdermal patches in two different age groups: 50-60 years and >75 years

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A Randomized, Double-blind, Placebo- and Active-controlled, Double-dummy, Parallel Group Study to Determine the Safety and Efficacy of Oxycodone/Naloxone Prolonged-release Tablets in Subjects with Moderate to Severe, Chronic Nonmalignant Pain To demonstrate the superiority of OXN over placebo on the time from the initial dose of study medication to multiple (ie, recurring) pain events (inadequate analgesia) during the Double-blind Phase.

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An exploratory, randomised, double-blind, single-dummy, placebo controlled, parallel group study to demonstrate the analgesic efficacy of oxycodone/naloxone prolonged release tablets (OXN PR) in addition to pregabalin compared to pregabalin alone in opioid-naïve subjects treated with pregabalin suffering from severe pain due to diabetic polyneuropathy To show superior analgesic efficacy of OXN PR in addition to a patient’s current dose of pregabalin compared to pregabalin alone based on the “Short-Form McGill Pain Questionnaire” assessed at each vi...

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Efficacy and Safety in a randomised acute pain study of MR308. Eficacia y Seguridad de MR308 en un estudio aleatorizado de dolor agudo To demonstrate the efficacy of MR308 doses in the Treatment of acute moderate to severe pain. Efficacy will be assessed by showing superiority of MR308 doses over Placebo and non-inferiority compared ...

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Intrathecal chemotherapy with liposomal ara-C (Depocyte) in leptomeningeal metastases of solid tumors: a phase III study The main objective is to assess the clinical benefits of treatment with DepoCyte® in comparison to no Intra Thecal (IT) therapy in adult patients with leptomeningeal metastasis (LM) from solid tumors.

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Mannitol challenge test in adult asthma patients with fixed dose combination - Pilot Explore if adult asthma patients prescribed fixed dose combinations (budenosid/formoterol (Symbicort®), salmeterol/fluticasone (Seretide®), beclometasone/formoterol (Innovair®)) are optimal treated re...

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