A TWO-ARM RANDOMIZED OPEN LABEL PHASE 2 STUDY OF CP-751,871 IN COMBINATION WITH EXEMESTANE VERSUS EXEMESTANE ALONE AS FIRST LINE TREATMENT FOR POSTMENOPAUSAL PATIENTS WITH HORMONE RECEPTOR POSITIVE ADVANCED BREAST CANCER To compare the efficacy, in terms of progression free survival (PFS), of CP-751,871 in combination with exemestane versus exemestane alone as first line treatment for hormone-dependent advanced brea...

• Country None
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• Specialty None

A PHASE 2A, RANDOMIZED, DOUBLE BLIND, PLACEBO-CONTROLLED, PARALLEL GROUP STUDY INVESTIGATING THE DOSE-RESPONSE OF PF-00489791 ON ACUTE HEMODYNAMICS IN SUBJECTS WITH IDIOPATHIC AND FAMILIAL PULMONARY ARTERIAL HYPERTENSION To evaluate the effect of different doses of PF-00489791 on PVRI in subjects with idiopathic and familial pulmonary arterial hypertension.

• Country None
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A study to find out if a vaccine designed to protect against a disease (group B meningococcal meningitis) is safe and protects toddlers aged 12 <18months or 18 < 24 months •To describe the immune response as measured by hSBA performed with 4 primary MnB strains, 2 expressing an LP2086 subfamily A protein and 2 expressing an LP2086 subfamily B protein, measured 1 month a...

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A pilot study to evaluate the use of pregabalin in the management of burning mouth syndrome Not provided at time of registration

• Country None
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A PHASE 3, RANDOMIZED, DOUBLE-BLIND, PARALLEL GROUP, 10-WEEK, PLACEBO CONTROLLED FIXED DOSE STUDY OF PD 0332334 AND PAROXETINE EVALUATING THE EFFICACY AND SAFETY OF PD 0332334 FOR THE TREATMENT OF GENERALIZED ANXIETY DISORDER To assess the efficacy of PD 0332334 in the treatment of GAD as measured by the change from Baseline in the HAM-A total score at Week 8. To assess the safety and tolerability of PD 0332334 in subjec...

• Country None
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PIZER PROFILE 1005 : Essai de phase 2 évaluant l’efficacité et la tolérance du PF-02341066 chez des patients ayant un cancer du poumon non à petites cellules avancé, avec translocation ou inversion au niveau du gène ALK (anaplastic lymphoma kinase). [essai clos aux inclusions] L’objectif de cet essai est d’évaluer l’efficacité et la tolérance PF-02341066 chez des patients ayant un cancer du poumon non à petites cellules avancé, avec translocation ou inversion au niveau du g...

• Country France
• organs Poumon, type non à petites cellules
• Specialty Thérapies Ciblées

ESTUDIO EN FASE 2, DE UN SOLO GRUPO, DE CP 751,871 EN PACIENTES CON ADENOCARCINOMA DE COLON O RECTO METASTÁSICO REFRACTARIO A PHASE II, SINGLE ARM STUDY OF CP-751,871 IN PATIENTS WITH REFRACTORY METASTATIC ADENOCARCINOMA OF THE COLON OR RECTUM Evaluar la supervivencia global a los seis meses en pacientes con cáncer colorrectal metastásico refractario que reciben CP-751,871.

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AN OPEN LABEL EXTENSION STUDY TO INVESTIGATE THE LONG TERM SAFETY, TOLERABILITY AND EFFICACY OF PF-02545920 IN SUBJECTS WITH HUNTINGTON’S DISEASE WHO PREVIOUSLY COMPLETED STUDY A8241021 - To assess long-term safety and tolerability of 20 mg BID of PF-02545920 in subjects with HD.

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A PHASE 3, MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, CONTROLLED STUDY OF THE LONG-TERM ANALGESIC EFFICACY AND SAFETY OF TANEZUMAB ALONE OR IN COMBINATION WITH NON-STEROIDAL ANTIINFLAMMATORY DRUGS (NSAIDS) VERSUS NSAIDS ALONE IN PATIENTS WITH OSTEOARTHRITIS OF THE KNEE OR HIP Primary Objective • Demonstrate superior efficacy of IV tanezumab 10 mg and 5 mg alone and in combination with an NSAID PO (naproxen 500 mg BID or celecoxib 100 mg BID) versus placebo in combination...

• Country None
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A LOCAL, MULTICENTRE, OPEN-LABEL, EXTENSION TRIAL TO EVALUATE THE EFFICACY AND SAFETY OF FESOTERODINE FLEXIBLE DOSE REGIMEN IN ELDERLY PATIENTS WITH OVERACTIVE BLADDER To assess the long-term efficacy, in terms of maintenance of Fesoterodine effect on urgency episode frequency in elderly subjects with OAB.

• Country None
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• Specialty None