A double-blind, randomized study looking at the efficacy, safety and tolerability of tafamidis meglumine (PF-06291826) 20 mg or 80 mg compared to placebo when taken daily by oral administration mouth in subjects diagnosed with transthyretin cardiomyopathy (TTR-CM) The primary objective of this study is to assess the efficacy of an oral dose of 20 mg or 80 mg tafamidis meglumine soft-gel capsules based on all-cause mortality and on frequency of cardiovascular-re...

• Country None
• organs None
• Specialty None

Pfizer XRP4174D-3001 : Essai de phase 3, randomisé comparant l’association au cisplatine de l’hydrochloride d’irinotécan ou de l’étoposide, chez des patients ayant un cancer du poumon à petites cellules de stade avancé. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] Open Label, Randomised Multicentre Phase III Study Of Irinotecan Hydrochloride (Campto (Registered)) And Cisplatin Versus Etoposide And Cisplatin In Chemotherapy Naive Patients With Extensive Disease ...

• Country France
• organs Poumon, type à petites cellules
• Specialty Chimiothérapie

Randomized, Parallel, Double-Blind, Placebo-Controlled Trial to Evaluate the Efficacy and Safety of SBI-087 in Seropositive Subjects With Active Rheumatoid Arthritis on a Stable Background of Methotrexate To evaluate clinical efficacy and safety of 4 SBI-087 SC dosing regimens versus placebo in seropositive subjects with active RA on a stable background of MTX

• Country None
• organs None
• Specialty None

RANDOMIZED, DOUBLE-BLIND PHASE 2 STUDY OF AXITINIB (AG-013736) WITH OR WITHOUT DOSE TITRATION IN PATIENTS WITH METASTATIC RENAL CELL CARCINOMA To compare the objective response rate (ORR) in patients receiving axitinib with or without dose titration (Arms A and B)

• Country None
• organs None
• Specialty None

AN INTERNATIONAL, MULTICENTER, LARGE SIMPLE TRIAL (LST) TO EVALUATE THE LONG-TERM PULMONARY AND CARDIOVASCULAR SAFETY OF EXUBERA® IN PATIENTS WITH DIABETES MELLITUS The primary objective of this study is to estimate the relative risk of a persistent decline in FEV1 exceeding 20% from baseline among subjects with diabetes randomized to Exubera as compared with tho...

• Country None
• organs None
• Specialty None

Pfizer A0081128 COPE : Essai de phase 4 randomisé, en double aveugle, évaluant l’efficacité et la tolérance de la prégabalin, en traitement de la douleur, chez des patients ayant des métastases osseuses. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] L’objectif de cet essai est d’évaluer l’efficacité et la tolérance de la prégabalin pour traiter la douleur osseuse, chez des patients ayant un cancer avec des métastases osseuses. Les patients seron...

• Country France
• organs Métastases osseuses, Os, Tumeurs solides
• Specialty Autres (cryothérapie, radiofréquence, homéopathie,...)

A PARALLEL-GROUP, RANDOMIZED, DOUBLE-BLIND, MULTI-CENTER DOSE RESPONSE STUDY TO EVALUATE THE EFFICACY AND SAFETY OF PF- 00885706, A 5-HT4 RECEPTOR PARTIAL AGONIST, AS ADD-ON THERAPY TO ESOMEPRAZOLE FOR THE RELIEF OF SYMPTOMS IN SUBJECTS WITH GASTRO-ESOPHAGEAL REFLUX DISEASE (GERD) WHO HAVE A POOR RESPONSE TO PROTON PUMP INHIBITOR (PPI) TREATMENT To understand the dose-response characteristics of PF-00885706 for efficacy in terms of symptomatic relief when used as add-on treatment to Esomeprazole 20mg (standard PPI treatment), in subjects with...

• Country None
• organs None
• Specialty None

A PHASE 3, MULTI-CENTER, RANDOMIZED, DOUBLE-BLIND, PLACEBOCONTROLLED, SAFETY AND EFFICACY STUDY OF SITAXSENTAN SODIUM IN SUBJECTS WITH PULMONARY ARTERIAL HYPERTENSION The primary objective of this study is to evaluate the efficacy of sitaxsentan (100 mg dose) as compared to placebo in the treatment of subjects with PAH for 12 weeks, as determined by change from the...

• Country None
• organs None
• Specialty None

A PHASE 2, RANDOMIZED, DOUBLE-BLIND, MULTI-DOSE, PLACEBO-CONTROLLED CROSSOVER STUDY OF THE EFFICACY OF FESOTERODINE IN INCREASING URETHRAL PRESSURE IN STRESS URINARY INCONTINENCE PATIENTS • To determine whether fesoterodine increases urethral tone relative to placebo in SUI patients.

• Country None
• organs None
• Specialty None

PALOMA-3 : Essai de phase 3 randomisé, en double-aveugle, évaluant l’efficacité de l’association du palbociclib (PD-0332991) à du fulvestrant, chez des patientes ayant un cancer du sein métastatique RH+/HER2- en progression après un traitement hormonal. [Informations issues du site clinicaltrials.gov et traduites par l'INCa] [essai clos aux inclusions] L’objectif de cet essai est de comparer l’efficacité du fulvestrant associé ou non à du palbociclib, chez des patientes ayant un cancer du sein RH+/HER2- métastatique, en progression après un traiteme...

• Country France
• organs Sein
• Specialty Thérapies Ciblées, Hormonothérapie