Evaluating the Safety of Immediate Versus Deferred Isoniazid Preventive Therapy Among HIV-Infected Pregnant Women Tuberculosis (TB) is a leading cause of death among HIV-infected persons in low-income settings and can be a serious complication for HIV-infected pregnant women and their infants. Isoniaz...

• Pays Botswana, Haiti, India, South Africa, Tanzania, United Republic of, Thailand, Uganda, Zimbabwe
• Organes Aucun
• Spécialités Aucune

Evaluation of the Safety, Efficacy, and Pharmacokinetics of Intravenous Deferiprone in HIV-Positive Subjects This study will evaluate the safety, tolerability, antiretroviral activity, pharmacokinetics, and pharmacodynamics of an intravenous formulation of deferiprone in HIV-infected subjects.

• Pays South Africa
• Organes Aucun
• Spécialités Aucune

A Study of Mavrilimumab in Subjects With Moderate-to-Severe Rheumatoid Arthritis The primary objective of this study is to evaluate the efficacy of 3 subcutaneous doses of mavrilimumab compared with placebo in combination with methotrexate (MTX) in subjects with modera...

• Pays Argentina, Bulgaria, Chile, Colombia, Czech Republic, Estonia, Germany, Hungary, Poland, Russian Federation, Serbia, South Africa, Spain, Ukraine
• Organes Aucun
• Spécialités Aucune

Study Evaluating Long-Term Safety Of ATN-103 In Subjects With Rheumatoid Arthritis This open-label extension study will allow subjects who have completed either the 3242K1-2000-WW or 3242K1-2001-JA study to receive up to an additional 48 weeks of ATN-103 treatment and wi...

• Pays Canada, Hungary, Japan, Russian Federation, Serbia, South Africa, Switzerland, United States
• Organes Aucun
• Spécialités Aucune

Efficacy, Safety and Immunogenicity Study of Recombinant Human C1 Inhibitor for the Treatment of Acute HAE Attacks This study is being conducted to confirm the efficacy, safety, and immunogenicity of recombinant human C1 inhibitor (rhC1INH) at a dose of 50 U/kg when used for the treatment of acute angi...

• Pays Bulgaria, Canada, Hungary, Israel, Italy, Macedonia, the former Yugoslav Republic of, Poland, Romania, Serbia, South Africa, United States
• Organes Aucun
• Spécialités Aucune

The use of chest physiotherapy in children hospitalised with pneumonia

• Pays South Africa
• Organes Aucun
• Spécialités Aucune

18-week add-on to Metformin Comparison of Saxagliptin and Sitagliptin in Adult Patients With Type 2 Diabetes (T2D) Saxagliptin is a new investigational medication being developed for treatment of type 2 diabetes. This study is designed to assess the efficacy and tolerability of saxagliptin in addition ...

• Pays Argentina, Belgium, Denmark, France, Italy, Mexico, Norway, South Africa, Sweden
• Organes Aucun
• Spécialités Aucune

Safety and Efficacy of Cariprazine in Schizophrenia The objective of this study is to evaluate the efficacy, safety, and tolerability of cariprazine relative to placebo for the treatment of acute exacerbation of schizophrenia.

• Pays Colombia, India, South Africa, United States
• Organes Aucun
• Spécialités Aucune

A Phase III, Multicentre, Double-Blind, Placebo-Controlled Withdrawal Study in Patients With Hyperphosphatemia This is a phase III multi-centre study in three periods: the first period is a phosphate binder washout for 4 weeks, the second period is an open-label, randomised, parallel group, flexibl...

• Pays Australia, Austria, Czech Republic, France, Germany, Hungary, Italy, Poland, South Africa, Spain, United Kingdom
• Organes Aucun
• Spécialités Aucune

Open-label Extension Study to Evaluate the Safety of USL255 in Patients With Refractory Partial-onset Seizures The purpose of this study is to examine the safety of USL255 as adjunctive therapy in patients with refractory partial onset-seizures.

• Pays Argentina, Australia, Belgium, Canada, Chile, Germany, Greece, India, Israel, New Zealand, Poland, Russian Federation, South Africa, Spain, United States
• Organes Aucun
• Spécialités Aucune